Results 91 to 100 of about 3,108,292 (291)

Length-Lex Open Constraints

, 2018
Open constraints were introduced to model the many industrial applications in which a task can be handled by several resources. Open constraints are unique because the set of variables over which the the constraint is defined is a set-variable. Regin and
Pascal van Hentenryck (5457176), Luc Mercier (5457185), Willem-Jan Van Hoeve (3895327), Gregoire Dooms (5457179), Laurent Michel (5457182)   +4 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Nonminimally coupled dark matter in clusters of galaxies: a fully comprehensive analysis

European Physical Journal C: Particles and Fields
In this study, we explore how a non-minimal coupling between dark matter and gravity can affect the behavior of dark matter in galaxy clusters. We have considered the case of a disformal coupling, which leads to a modification of the Poisson equation ...
Saboura Zamani, Vincenzo Salzano, Dario Bettoni   +2 more
doaj   +1 more source

Coupling characteristics of two uniform microfibers

, 2013
The coupling characteristics of two uniform microfibers are experimentally demonstrated. The uniform microfiber is fabricated from a silica-based single mode fiber (SMF) using an oxy-butane flame-brushing method.
Harun, Sulaiman Wadi, Ahmad, Harith, Zulkifli, Ahmad Zarif, Jasim, Ali Abdulhadi, Dimyati, Kaharudin, Arof, Hamzah   +5 more
core  

Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland? [PDF]

, 2012
Background <p> The search for biomarkers of aging (BoAs) has been largely unsuccessful to-date and there is widespread skepticism about the prospects of finding any that satisfy the criteria developed by the American Federation of Aging Research ...
Batty, G.D., Robertson, T., Shiels, PG, Shiels Paul G., Benzeval, Michaela, Michaela Benzeval, McGlynn, Liane, G David Batty, Ian J Deary, McIntyre, A., McIntyre, A, Michael J Green, Benzeval, M, Tony Robertson, Der, G, Alan McIntyre, Paul G Shiels, McIntyre Alan, Robertson, Tony, Shiels, Paul G, Green, Michael J, Green, M.J., McGlynn Liane, McIntyre, Alan, Deary, Ian J, Der, Geoff, Robertson, T, Geoff Der, Green, MJ, McGlynn, L., McGlynn, L, Green Michael J., Deary, Ian, Deary Ian J., Der, G., Liane McGlynn, Batty G. David, McGlynn, Liane M, Robertson Tony, Batty, GD, Benzeval, M., Shiels, P.G., Batty, G David, Benzeval Michaela, Deary, IJ, Deary, I.J., Der Geoff   +46 more
core   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Optical Coupling Structures of Fiber-Optic Mach-Zehnder Interferometers Using CO2 Laser Irradiation

International Journal of Antennas and Propagation, 2014
The Mach-Zehnder interferometer (MZI) can be used to test changes in the refractive index of sucrose solutions at different concentrations. However, the popularity of this measurement tool is limited by its substantial size and portability.
Chien-Hsing Chen, Chih-Yu Hsu, Pei-Hsing Huang, Jian-Neng Wang, Wei-Te Wu   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source