Results 11 to 20 of about 157,324 (326)

A theoretical approach to coupling the epithelial-mesenchymal transition (EMT) to extracellular matrix (ECM) stiffness via LOXL2 [PDF]

Cancers, 2021
Abstract The epithelial-mesenchymal transition (EMT) plays a critical role in cancer progression, being responsible in many cases for the onset of the metastatic cascade and being integral in the ability of cells to resist drug treatment. Most studies of EMT focus on its induction via chemical signals such as TGF-β or Notch ligands, but
Youyuan Deng, Priyanka Chakraborty, Mohit Kumar Jolly, Herbert Levine   +3 more
openaire   +4 more sources

Extracellular matrix stiffness regulates human airway smooth muscle contraction by altering the cell-cell coupling [PDF]

Scientific Reports, 2019
Abstract For an airway or a blood vessel to narrow, there must be a connected path that links the smooth muscle (SM) cells with each other, and transmits forces around the organ, causing it to constrict. Currently, we know very little about the mechanisms that regulate force transmission pathways in a multicellular SM ensemble.
Polio, Samuel R., Stasiak, Suzanne E., Jamieson, Ryan R., Balestrini, Jenna L., Krishnan, Ramaswamy, Parameswaran, Harikrishnan   +5 more
openaire   +3 more sources

Thermally affected stiffness matrix of angular contact ball bearings in a high-speed spindle system

Advances in Mechanical Engineering, 2019
Bearing stiffness directly affects the dynamic characteristics in a high-speed spindle system and plays an important role in terms of manufacturing quality.
Dinh Sy Truong, Byung-Sub Kim, Jong-Kweon Park   +2 more
doaj   +2 more sources

Interplay of matrix stiffness and protein tethering in stem cell differentiation [PDF]

Nature Materials, 2014
Stem cells regulate their fate by binding to, and contracting against, the extracellular matrix. Recently, it has been proposed that in addition to matrix stiffness and ligand type, the degree of coupling of fibrous protein to the surface of the ...
Hribar, KC, Wen, Jessica H, Taylor-Weiner, Hermes, Vincent, LG, Wen, JH, Chen, S, Taylor-Weiner, H, Vincent, Ludovic G, Choi, YS, Choi, Yu Suk, Hribar, Kolin C, Fuhrmann, Alexander, Engler, Adam J, Engler, AJ, Chen, Shaochen, Fuhrmann, A   +15 more
core   +2 more sources

A Protein-Adsorbent Hydrogel with Tunable Stiffness for Tissue Culture Demonstrates Matrix-Dependent Stiffness Responses

Advanced Functional Materials
Although tissue culture plastic has been widely employed for cell culture, the rigidity of plastic is not physiologic. Softer hydrogels used to culture cells have not been widely adopted in part because coupling chemistries are required to covalently ...
Chen, Christopher S., Eyckmans, Jeroen, Li, Linqing, Griebel, Megan E., Trappmann, Britta, Bubli, Saniya Yesmin, Gagnon, Keith A., Baker, Brendon M., Uroz, Marina   +8 more
core   +2 more sources

Optimization study of finite element simulation based on multi-layer structure and anisotropic CFRP

Frontiers in Materials, 2023
Introduction: Current research has mostly simplified CFRP components as isotropic media or homogenized them as anisotropic media, which fails to present the actual acoustic propagation behavior inside the CFRP components and restricts the accuracy of ...
Qin Yu-xin, Xiong Xin-meng, Zhang Wen-li
doaj   +1 more source

A Substructure Condensed Approach for Kinetostatic Modeling of Compliant Mechanisms with Complex Topology

Micromachines, 2022
Compliant mechanisms with complex topology have previously been employed in various precision devices due to the superiorities of high precision and compact size.
Shilei Wu, Zhongxi Shao, Hongya Fu
doaj   +1 more source

Effect of microstructure evolution on the mechanical behavior of magneto-active elastomers with different matrix stiffness.

Soft Matter, 2023
Evolution of microstructure in magneto-active elastomers (MAEs) which can be caused by an applied magnetic field is a fascinating phenomenon with a significant impact on the mechanical behavior of the composite.
M. Roghani, D. Romeis, M. Saphiannikova
semanticscholar   +1 more source

General Stiffness Matrix for a Thin-Walled, Open-Section Beam Structure

World Journal of Mechanics, 2021
This paper is to review the theory of thin-walled beam structures of the open cross-section. There is scant information on the performance of structures made from thin-walled beam elements, particularly those of open sections, where the behavior is ...
Abdelraouf M. Sami Alsheikh, D. Rees
semanticscholar   +1 more source

Type Synthesis of Fully Decoupled Three Translational Parallel Mechanism with Closed-Loop Units and High Stiffness

Chinese Journal of Mechanical Engineering, 2023
In order to solve the problem of weak stiffness of the existing fully decoupled parallel mechanism, a new synthesis method of fully decoupled three translational (3T) parallel mechanisms (PMs) with closed-loop units and high stiffness is proposed based ...
Shihua Li, Sen Wang, Haoran Li, Yongjie Wang, Shuang Chen   +4 more
doaj   +1 more source