Results 1 to 10 of about 156,207 (308)
Cancer Communications, 2022 Background Despite integrin being highlighted as a stiffness‐sensor molecule in matrix stiffness‐driven angiogenesis, other stiffness‐sensor molecules and their mechanosensory pathways related to angiogenesis in hepatocellular carcinoma (HCC) remain ...
Miao Li +15 more
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The role of matrix stiffness in breast cancer progression: a review
Frontiers in Oncology, 2023 The significance of matrix stiffness in cancer development has been investigated in recent years. The gradual elastic force the extracellular matrix imparts to cells, known as matrix stiffness, is one of the most important types of mechanical stimulation.
Ruoxi Xu +4 more
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Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism
Frontiers in Oncology, 2021 In recent years, in-depth studies have shown that extracellular matrix stiffness plays an important role in cell growth, proliferation, migration, immunity, malignant transformation, and apoptosis.
Heming Ge +4 more
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Tumor matrix stiffness provides fertile soil for cancer stem cells
Cancer Cell International, 2023 Matrix stiffness is a mechanical characteristic of the extracellular matrix (ECM) that increases from the tumor core to the tumor periphery in a gradient pattern in a variety of solid tumors and can promote proliferation, invasion, metastasis, drug ...
Sadegh Safaei +7 more
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Biological role of matrix stiffness in tumor growth and treatment
Journal of Translational Medicine, 2022 In recent years, the biological role of changes in physical factors in carcinogenesis and progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is a critical physical factor of tumor microenvironment and remains ...
Boer Deng +5 more
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Matrix Stiffness Contributes to Cancer Progression by Regulating Transcription Factors
Cancers, 2022 Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression. Recent studies have shown that matrix stiffening is caused by the accumulation, contraction, and crosslinking of the extracellular matrix by cancer and stromal ...
Seiichiro Ishihara, Hisashi Haga
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3D matrix stiffness modulation unveils cardiac fibroblast phenotypic switching
Scientific ReportsThis study investigates how dynamic fluctuations in matrix stiffness affect the behavior of cardiac fibroblasts (CFs) within a three-dimensional (3D) hydrogel environment.
Yan Han +8 more
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Matrix stiffness regulates osteoclast fate through integrin-dependent mechanotransduction
Bioactive Materials, 2023 Osteoclasts ubiquitously participate in bone homeostasis, and their aberration leads to bone diseases, such as osteoporosis. Current clinical strategies by biochemical signaling molecules often perturb innate bone metabolism owing to the uncontrolled ...
Xiaogang Wang +3 more
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Influence of the Order Exchange of the Node Connection in the Force Analysis of Steel Structures
Frontiers in Materials, 2022 In the mechanical analysis of steel structures, whether it is static analysis or dynamic analysis, it is necessary to establish the structural stiffness matrix first.
Shuai Luo +4 more
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Stiffness analysis of a 3-DOF parallel mechanism for engineering special machining [PDF]
Mechanical Sciences, 2022 There are considerably rigorous requirements for accuracy and stability of the mechanism to accomplish large-scale and complex surface machining tasks in the aerospace field.
H. Zhang +7 more
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