Results 1 to 10 of about 128,748 (119)
Matrix stiffness and its influence on pancreatic diseases
Biochimica Et Biophysica Acta: Reviews on Cancer, 2021 The matrix stiffness of the extracellular matrix(ECM), which is the slow elastic force on cells, has gradually become investigated. And a higher stiffness could induce changes in cell biological behaviors and activation of internal signaling pathways. Imbalanced stiffness of ECM is associated with a number of diseases, including pancreatic disease.
Wunai Zhang, Weikun Qian
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Matrix stiffness, endothelial dysfunction and atherosclerosis
Molecular Biology Reports, 2022 Abstract Background Atherosclerosis (AS) is the leading cause of the human cardiovascular disease (CVDs). Endothelial dysfunction promotes the monocytes infiltration and inflammation that participate fundamentally in atherogenesis. Endothelial cells (EC) have been recognized as mechanosensitive cells and have different responses to distinct ...
Zichen Xu +7 more
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Matrix Stiffness and Colorectal Cancer.
OncoTargets and therapy, 2020 In recent years, a growing consensus is emerging that the mechanical microenvironment of tumors is far more critical in the onset of tumor, tumor progression, invasion, and metastasis. Matrix stiffness, one of the sources of mechanical stimulation, affects tumor cells as well as non-tumor cells in multiple different molecular signaling pathways in ...
Liu,Chongshun, Pei,Haiping, Tan,Fengbo
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Effect of matrix stiffness on osteoblast functionalization [PDF]
Cell Proliferation, 2017 AbstractObjectivesStiffness of bone tissue differs response to its physiological or pathological status, such as osteoporosis or osteosclerosis. Consequently, the function of cells residing in bone tissue including osteoblasts (OBs), osteoclasts and osteocytes will be affected.
Tao Zhang +8 more
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Matrix stiffness regulates macrophage polarization in atherosclerosis
Pharmacological Research, 2022 Atherosclerosis is a chronic inflammatory disease and the pathological basis of many fatal cardiovascular diseases. Macrophages, the main inflammatory cells in atherosclerotic plaque, have a paradox role in disease progression. In response to different microenvironments, macrophages mainly have two polarized directions: pro-inflammatory macrophages and
Yin, Wang +8 more
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Dynamic Stiffness Matrix of Sagging Cable [PDF]
Journal of Engineering Mechanics, 1991 The dynamic behavior of an extensible sagging cable is investigated. A dynamic stiffness matrix is presented whose coefficients are functions of the frequency of motion, and that is suitable for dynamic direct-stiffness analysis of composed systems such as cable-stayed bridges and guyed masts.
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The effect of matrix stiffness on biomechanical properties of chondrocytes [PDF]
Acta Biochimica et Biophysica Sinica, 2016 The behavior of chondrocytes is regulated by multiple mechanical microenvironmental cues. During development and degenerative disease of articular cartilage, as an external signal, the extracellular matrix stiffness of chondrocytes changes significantly, but whether and how this biophysical cue affects biomechanical properties of chondrocytes remain ...
Quanyou, Zhang, Yang, Yu, Hucheng, Zhao
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European Journal of Translational Myology, 2019 The assessment of soft tissue stiffness is important to evaluate many neuromusculoskeletal conditions. Several tools have been proposed for the assessment of stiffness, but ultrasonography appears to be most practical. The reflection of ultrasound waves as it travels through tissue enables assessment of tissue echogenicity, which is influenced by the ...
Stecco, A +3 more
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Organ sculpting by patterned extracellular matrix stiffness
eLife, 2017 How organ-shaping mechanical imbalances are generated is a central question of morphogenesis, with existing paradigms focusing on asymmetric force generation within cells. We show here that organs can be sculpted instead by patterning anisotropic resistance within their extracellular matrix (ECM).
Justin Crest +4 more
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Exploiting Matrix Stiffness to Overcome Drug Resistance
ACS Biomaterials Science & EngineeringDrug resistance is arguably one of the biggest challenges facing cancer research today. Understanding the underlying mechanisms of drug resistance in tumor progression and metastasis are essential in developing better treatment modalities. Given the matrix stiffness affecting the mechanotransduction capabilities of cancer cells, characterization of the
Hakan Berk Aydin +2 more
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