Results 1 to 10 of about 1,991,561 (300)

Activation of Piezo1 contributes to matrix stiffness‐induced angiogenesis in hepatocellular carcinoma

open access: yesCancer Communications, 2022
Background Despite integrin being highlighted as a stiffness‐sensor molecule in matrix stiffness‐driven angiogenesis, other stiffness‐sensor molecules and their mechanosensory pathways related to angiogenesis in hepatocellular carcinoma (HCC) remain ...
Miao Li   +15 more
doaj   +2 more sources

The role of matrix stiffness in breast cancer progression: a review

open access: yesFrontiers in Oncology, 2023
The significance of matrix stiffness in cancer development has been investigated in recent years. The gradual elastic force the extracellular matrix imparts to cells, known as matrix stiffness, is one of the most important types of mechanical stimulation.
Ruoxi Xu   +4 more
doaj   +3 more sources

Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism

open access: yesFrontiers in Oncology, 2021
In recent years, in-depth studies have shown that extracellular matrix stiffness plays an important role in cell growth, proliferation, migration, immunity, malignant transformation, and apoptosis.
Heming Ge   +4 more
doaj   +3 more sources

Influence of the Order Exchange of the Node Connection in the Force Analysis of Steel Structures

open access: yesFrontiers in Materials, 2022
In the mechanical analysis of steel structures, whether it is static analysis or dynamic analysis, it is necessary to establish the structural stiffness matrix first.
Shuai Luo   +4 more
doaj   +1 more source

Stiffness analysis of a 3-DOF parallel mechanism for engineering special machining [PDF]

open access: yesMechanical Sciences, 2022
There are considerably rigorous requirements for accuracy and stability of the mechanism to accomplish large-scale and complex surface machining tasks in the aerospace field.
H. Zhang   +7 more
doaj   +1 more source

Nonswelling and Hydrolytically Stable Hydrogels Uncover Cellular Mechanosensing in 3D

open access: yesAdvanced Science, 2022
While matrix stiffness regulates cell behavior on 2D substrates, recent studies using synthetic hydrogels have suggested that in 3D environments, cell behavior is primarily impacted by matrix degradability, independent of stiffness.
Hongyan Long   +4 more
doaj   +1 more source

Three-dimensional decellularized tumor extracellular matrices with different stiffness as bioengineered tumor scaffolds

open access: yesBioactive Materials, 2021
In the three-dimensional (3D) tumor microenvironment, matrix stiffness is associated with the regulation of tumor cells behaviors. In vitro tumor models with appropriate matrix stiffness are urgently desired.
Yonggang Lv   +3 more
doaj   +1 more source

Modeling the effect of fracture orientation on porus media anisotropy using the T-matrix method [PDF]

open access: yesНефтегазовая геология: Теория и практика, 2022
Fracture orientation is crucial in porous media anisotropy. In the current study we investigate the role of fracture orientation based on a novel Rock Physics method - the T-matrix approach. This method allows us to study the fracture porosity, shape and
Goleij F.
doaj   +1 more source

Exact Solutions for Torsion and Warping of Axial-Loaded Beam-Columns Based on Matrix Stiffness Method

open access: yesNanomaterials, 2022
The typically-used element torsional stiffness GJ/L (where G is the shear modulus, J the St. Venant torsion constant, and L the element length) may severely underestimate the torsional stiffness of thin-walled nanostructural members, due to neglecting ...
Wen-Hao Pan   +3 more
doaj   +1 more source

Heterogeneous matrix stiffness regulates the cancer stem-like cell phenotype in hepatocellular carcinoma

open access: yesJournal of Translational Medicine, 2022
Background Solid tumors are stiffer than their surrounding normal tissues; however, their interior stiffness is not uniform. Under certain conditions, cancer cells can acquire stem-like phenotypes.
Jiayun Wei   +11 more
doaj   +1 more source

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