Results 41 to 50 of about 1,991,561 (300)

Stability and vibration analyses of tapered columns resting on one or two-parameter elastic foundations [PDF]

open access: yesNumerical Methods in Civil Engineering, 2014
This paper presents a generalized numerical method to evaluate element stiffness matrices needed for the free vibration and stability analyses of non-prismatic columns resting on one- or two-parameter elastic foundations and subjected to variable axial ...
Masoumeh Soltani, Foudil Mohri
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

open access: yesFEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual   +3 more
wiley   +1 more source

Image4_Novel Brain-Stiffness-Mimicking Matrix Gel Enables Comprehensive Invasion Analysis of 3D Cultured GBM Cells.jpg

open access: yes, 2022
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults, which is fast growing and tends to invade surrounding normal brain tissues.
Jin Xiong (3359327)   +12 more
core   +1 more source

Modelling of thin-walled members with restrained torsion considering the section properties

open access: yesMagazine of Civil Engineering, 2023
Various engineering structures include lightweight or thin-walled beam structures that are used in a complex loading situation which includes restrained torsion of closed or open section. The importance of restrained torsion of thin-walled cross-sections
Gebre Tesfaldet   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Modèles élastiques et élasto‐dynamiques de robots porteurs [PDF]

open access: yes, 2012
The report presents an advanced stiffness modeling technique for parallel manipulators composed of perfect and non-perfect serial chains. The developed technique contributes both to the stiffness modeling of serial and parallel manipulators under ...
KLIMCHIK, Alexandr, PASHKEVICH, Anatol
core  

Metabolic enzyme PFKFB3 mediates matrix stiffness‐potentiated tumour growth and radiotherapeutic resistance in HCC

open access: yesClinical and Translational Medicine
Background Although the contribution of matrix stiffness to aggravating the malignant features of HCC cells has been well documented, the effects of matrix stiffness on chemoradiotherapy resistance and its underlying mechanism remain largely elusive ...
Mimi Wang   +14 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

open access: yesMolecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

The effect of matrix stiffness on biomechanical properties of chondrocytes [PDF]

open access: yesActa Biochimica et Biophysica Sinica, 2016
The behavior of chondrocytes is regulated by multiple mechanical microenvironmental cues. During development and degenerative disease of articular cartilage, as an external signal, the extracellular matrix stiffness of chondrocytes changes significantly, but whether and how this biophysical cue affects biomechanical properties of chondrocytes remain ...
Quanyou, Zhang, Yang, Yu, Hucheng, Zhao
openaire   +2 more sources

Immersion and Invariance Control for an Antagonistic Joint with Nonlinear Mechanical Stiffness [PDF]

open access: yes, 2010
Tendon controlled robots with nonlinear mechanical tendon stiffness are becoming more and more popular. With the appropriate actuation, the joint position and the stiffness between motor and link side can be prescribed at the same time. In this paper,
Hirzinger, Gerd   +5 more
core   +1 more source

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