Cancer Communications, 2022 Background Despite integrin being highlighted as a stiffness‐sensor molecule in matrix stiffness‐driven angiogenesis, other stiffness‐sensor molecules and their mechanosensory pathways related to angiogenesis in hepatocellular carcinoma (HCC) remain ...
Miao Li +15 more
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The role of matrix stiffness in breast cancer progression: a review
Frontiers in Oncology, 2023 The significance of matrix stiffness in cancer development has been investigated in recent years. The gradual elastic force the extracellular matrix imparts to cells, known as matrix stiffness, is one of the most important types of mechanical stimulation.
Ruoxi Xu +4 more
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Metabolic enzyme PFKFB3 mediates matrix stiffness‐potentiated tumour growth and radiotherapeutic resistance in HCC [PDF]
Clinical and Translational MedicineBackground Although the contribution of matrix stiffness to aggravating the malignant features of HCC cells has been well documented, the effects of matrix stiffness on chemoradiotherapy resistance and its underlying mechanism remain largely elusive ...
Mimi Wang +14 more
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Tumor matrix stiffness provides fertile soil for cancer stem cells
Cancer Cell International, 2023 Matrix stiffness is a mechanical characteristic of the extracellular matrix (ECM) that increases from the tumor core to the tumor periphery in a gradient pattern in a variety of solid tumors and can promote proliferation, invasion, metastasis, drug ...
Sadegh Safaei +7 more
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PKM2 mediates the glycolytic response to matrix stiffness in lung fibroblasts [PDF]
Frontiers in Cell and Developmental BiologyIntroductionMatrix stiffening during idiopathic pulmonary fibrosis (IPF) creates a mechanically altered microenvironment that promotes fibroblast activation, yet the metabolic consequences of these mechanical cues remain incompletely defined.
Yuan Wang +5 more
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Matrix stiffness in osteoarthritis: from mechanism introduction to biomaterial-based therapies [PDF]
Frontiers in EndocrinologyOsteoarthritis (OA), the most prevalent joint disorder associated with aging, is characterized by impaired extracellular matrix (ECM) synthesis and the degradation of articular cartilage.
Kai Huang, Haili Cai
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Matrix Stiffness Contributes to Cancer Progression by Regulating Transcription Factors
Cancers, 2022 Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression. Recent studies have shown that matrix stiffening is caused by the accumulation, contraction, and crosslinking of the extracellular matrix by cancer and stromal ...
Seiichiro Ishihara, Hisashi Haga
exaly +2 more sources
Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism
Frontiers in Oncology, 2021 In recent years, in-depth studies have shown that extracellular matrix stiffness plays an important role in cell growth, proliferation, migration, immunity, malignant transformation, and apoptosis.
Heming Ge +4 more
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3D matrix stiffness modulation unveils cardiac fibroblast phenotypic switching
Scientific ReportsThis study investigates how dynamic fluctuations in matrix stiffness affect the behavior of cardiac fibroblasts (CFs) within a three-dimensional (3D) hydrogel environment.
Yan Han +8 more
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Extracellular matrix stiffness regulates the proliferation and migration capacities of lymphatic endothelial cells via FAT1 [PDF]
Frontiers in Cell and Developmental BiologyIntroductionThe extracellular matrix (ECM) stiffness serves as a critical biomechanical regulator of cellular behavior. However, its specific roles on lymphatic endothelial cells (LECs) remains poorly characterized, particularly in the context of ...
Zhangrun Xu +14 more
doaj +2 more sources