Cancer Communications, 2022 Background Despite integrin being highlighted as a stiffness‐sensor molecule in matrix stiffness‐driven angiogenesis, other stiffness‐sensor molecules and their mechanosensory pathways related to angiogenesis in hepatocellular carcinoma (HCC) remain ...
Miao Li +15 more
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Metabolic enzyme PFKFB3 mediates matrix stiffness‐potentiated tumour growth and radiotherapeutic resistance in HCC [PDF]
Clinical and Translational MedicineBackground Although the contribution of matrix stiffness to aggravating the malignant features of HCC cells has been well documented, the effects of matrix stiffness on chemoradiotherapy resistance and its underlying mechanism remain largely elusive ...
Mimi Wang +14 more
doaj +2 more sources
Matrix stiffness and its influence on pancreatic diseases
Biochimica Et Biophysica Acta: Reviews on Cancer, 2021 The matrix stiffness of the extracellular matrix(ECM), which is the slow elastic force on cells, has gradually become investigated. And a higher stiffness could induce changes in cell biological behaviors and activation of internal signaling pathways. Imbalanced stiffness of ECM is associated with a number of diseases, including pancreatic disease.
Weikun Qian
exaly +3 more sources
Matrix Stiffness Induces Endothelial Network Senescence. [PDF]
Adv Sci (Weinh)Abstract Identifying the drivers of cellular senescence that contribute to the decline in tissue function related to aging- and disease is critical for developing restorative interventions. Here, we investigated how increased mechanical stress from extracellular matrix (ECM) stiffening shapes endothelial cell (EC ...
Song J +6 more
europepmc +4 more sources
PKM2 mediates the glycolytic response to matrix stiffness in lung fibroblasts [PDF]
Frontiers in Cell and Developmental BiologyIntroductionMatrix stiffening during idiopathic pulmonary fibrosis (IPF) creates a mechanically altered microenvironment that promotes fibroblast activation, yet the metabolic consequences of these mechanical cues remain incompletely defined.
Yuan Wang +5 more
doaj +2 more sources
Matrix stiffness may drive multi-cellular crosstalk via YAP signaling in biliary atresia liver fibrosis: a mechanistic review [PDF]
Frontiers in Cell and Developmental BiologyBackgroundBiliary atresia (BA) is a devastating liver disease in infants. It leads to progressive cholangitis and fibrosis. In BA, the liver builds up too much extracellular matrix (ECM) and crosslinks it.
Jiwen Cheng
doaj +2 more sources
Extracellular matrix stiffness regulates the proliferation and migration capacities of lymphatic endothelial cells via FAT1 [PDF]
Frontiers in Cell and Developmental BiologyIntroductionThe extracellular matrix (ECM) stiffness serves as a critical biomechanical regulator of cellular behavior. However, its specific roles on lymphatic endothelial cells (LECs) remains poorly characterized, particularly in the context of ...
Zhangrun Xu +14 more
doaj +2 more sources
The role of matrix stiffness in breast cancer progression: a review
Frontiers in Oncology, 2023 The significance of matrix stiffness in cancer development has been investigated in recent years. The gradual elastic force the extracellular matrix imparts to cells, known as matrix stiffness, is one of the most important types of mechanical stimulation.
Ruoxi Xu +4 more
doaj +1 more source
Influence of the Order Exchange of the Node Connection in the Force Analysis of Steel Structures
Frontiers in Materials, 2022 In the mechanical analysis of steel structures, whether it is static analysis or dynamic analysis, it is necessary to establish the structural stiffness matrix first.
Shuai Luo +4 more
doaj +1 more source
Stiffness analysis of a 3-DOF parallel mechanism for engineering special machining [PDF]
Mechanical Sciences, 2022 There are considerably rigorous requirements for accuracy and stability of the mechanism to accomplish large-scale and complex surface machining tasks in the aerospace field.
H. Zhang +7 more
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