Results 41 to 50 of about 1,985,960 (297)

Matrix stiffness regulates macrophage polarization in atherosclerosis

Pharmacological Research, 2022
Atherosclerosis is a chronic inflammatory disease and the pathological basis of many fatal cardiovascular diseases. Macrophages, the main inflammatory cells in atherosclerotic plaque, have a paradox role in disease progression. In response to different microenvironments, macrophages mainly have two polarized directions: pro-inflammatory macrophages and
Yin, Wang, Ruotong, Shi, Ran, Zhai, Shiyan, Yang, Tianqi, Peng, Fuwen, Zheng, YanNan, Shen, Meiying, Li, Lisha, Li   +8 more
openaire   +2 more sources

Stiffness of clays and silts: Modeling considerations [PDF]

, 2014
A large database has recently been published that details the development of new empirical expressions for the stiffness reduction with strain of clays and silts.
Vardanega, Paul J, Bolton, Malcolm
core   +1 more source

Using Polyacrylamide Hydrogels to Model Physiological Aortic Stiffness Reveals that Microtubules Are Critical Regulators of Isolated Smooth Muscle Cell Morphology and Contractility

Frontiers in Pharmacology, 2022
Vascular smooth muscle cells (VSMCs) are the predominant cell type in the medial layer of the aortic wall and normally exist in a quiescent, contractile phenotype where actomyosin-derived contractile forces maintain vascular tone.
Sultan Ahmed, Robert. T. Johnson, Reesha Solanki, Teclino Afewerki, Finn Wostear, Derek. T. Warren   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Elucidating the role of matrix stiffness in 3D cell migration and remodeling [PDF]

, 2011
Reductionist in vitro model systems which mimic specific extracellular matrix functions in a highly controlled manner, termed artificial extracellular matrices (aECM), have increasingly been used to elucidate the role of cell-ECM interactions in ...
Sala, A, Ranga, A., Bittermann, A, A. Sala, M.P. Lutolf, Lienemann, Philipp, Rizzi, Simone, Sala, A., K. Mosiewicz, A. Ranga, Rizzi, S.C., Weber, F. E., Ehrbar, Martin, Rizzi, S C, Lienemann, P, Sala, Ana, Mosiewicz, K, Mosiewicz, Katarzyna, Bittermann, A., Lutolf, M.P., S.C. Rizzi, M. Ehrbar, Lutolf, Matthias, Weber, Franz E; https://orcid.org/, Rizzi, S. C., Mosiewicz, K., Lutolf, M. P., Ehrbar, M; https://orcid.org/, Lutolf, M P, Bittermann, Anne Greet, A. Bittermann, P. Lienemann, Weber, Franz, F.E. Weber, Lienemann, P., Ehrbar, M., Weber, F.E., Ranga, A   +37 more
core   +2 more sources

Image2_Novel Brain-Stiffness-Mimicking Matrix Gel Enables Comprehensive Invasion Analysis of 3D Cultured GBM Cells.jpg

, 2022
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults, which is fast growing and tends to invade surrounding normal brain tissues.
Jin Xiong (3359327), Yaqi Li (2936265), Shuang Dong (3816961), Shuowen Wang (2294389), Zehao Yang (4115164), Yiqi Wang (2007934), Guang Han (529174), Wendai Bao (12841574), Junrong Lei (12841577), Sheng Hu (291314), Jun Qin (56379), Yu Qian (153240), Zhiqiang Dong (167671)   +12 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Image4_Novel Brain-Stiffness-Mimicking Matrix Gel Enables Comprehensive Invasion Analysis of 3D Cultured GBM Cells.jpg

, 2022
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults, which is fast growing and tends to invade surrounding normal brain tissues.
Jin Xiong (3359327), Yaqi Li (2936265), Shuang Dong (3816961), Shuowen Wang (2294389), Zehao Yang (4115164), Yiqi Wang (2007934), Guang Han (529174), Wendai Bao (12841574), Junrong Lei (12841577), Sheng Hu (291314), Jun Qin (56379), Yu Qian (153240), Zhiqiang Dong (167671)   +12 more
core   +1 more source

Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning

Cell Reports, 2021
Summary: While the immediate and transitory response of breast cancer cells to pathological stiffness in their native microenvironment has been well explored, it remains unclear how stiffness-induced phenotypes are maintained over time after cancer cell ...
Adam W. Watson, Adam D. Grant, Sara S. Parker, Samantha Hill, Michael B. Whalen, Jayati Chakrabarti, Michael W. Harman, Mackenzie R. Roman, Brittany L. Forte, Cody C. Gowan, Raúl Castro-Portuguez, Lindsey K. Stolze, Christian Franck, Darren A. Cusanovich, Yana Zavros, Megha Padi, Casey E. Romanoski, Ghassan Mouneimne   +17 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source