Results 51 to 60 of about 156,207 (304)
TRPV4 Plays a Role in Matrix Stiffness-Induced Macrophage Polarization
Frontiers in Immunology, 2020 Phenotypic polarization of macrophages is deemed essential in innate immunity and various pathophysiological conditions. We have now determined key aspects of the molecular mechanism by which mechanical cues regulate macrophage polarization. We show that
Bidisha Dutta +2 more
doaj +1 more source
Gels, 2023 This study investigates the intricate dynamics of matrix stiffness, substrate composition, and cell–cell interactions and elucidates their cumulative effects on fibroblast behavior in different culture contexts.
A Yeon Cho, Hyun Jong Lee
doaj +1 more source
, 2020 Although the matricellular protein periostin is prominently upregulated in skin and gingival healing, it plays contrasting roles in myofibroblast differentiation and matrix synthesis respectively.
Nikoloudaki, Georgia +4 more
core +1 more source
Microglia mechanics : immune activation alters traction forces and durotaxis
, 2015 This work was supported by the Austrian Agency for International Cooperation in Education and Research (Scholarship to LB), Faculty of Computer Science and Biomedical Engineering at Graz University of Technology (Scholarship to LB), German National ...
Gather, M. +32 more
core +1 more source
Matrix Stiffness Affects Glycocalyx Expression in Cultured Endothelial Cells
Frontiers in Cell and Developmental Biology, 2021 Rationale: The endothelial cell glycocalyx (GCX) is a mechanosensor that plays a key role in protecting against vascular diseases. We have previously shown that age/disease mediated matrix stiffness inhibits the glycocalyx glycosaminoglycan heparan ...
Marwa Mahmoud +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The Importance of Mechanical Forces for in vitro Endothelial Cell Biology
Frontiers in Physiology, 2020 Blood and lymphatic vessels are lined by endothelial cells which constantly interact with their luminal and abluminal extracellular environments. These interactions confer physical forces on the endothelium, such as shear stress, stretch and stiffness ...
Emma Gordon, Lilian Schimmel, Maike Frye
doaj +1 more source
Osteocyte differentiation and the formation of an interconnected cellular network in vitro [PDF]
European Cells & Materials, 2016 Extracellular matrix (ECM) stiffness and cell density can regulate osteoblast differentiation in two dimensional environments. However, it is not yet known how osteoblast-osteocyte differentiation is regulated within a 3D ECM environment, akin to that ...
MJ Mc Garrigle +4 more
doaj +1 more source
Modèles élastiques et élasto‐dynamiques de robots porteurs [PDF]
, 2012 The report presents an advanced stiffness modeling technique for parallel manipulators composed of perfect and non-perfect serial chains. The developed technique contributes both to the stiffness modeling of serial and parallel manipulators under ...
KLIMCHIK, Alexandr, PASHKEVICH, Anatol
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source