Results 21 to 30 of about 1,985,960 (297)

Joint Stiffness Identification of a Heavy Kuka Robot with a Low-cost Clamped End-effector Procedure [PDF]

open access: yes, 2014
This paper proposes two new methods for the identification of static stiffnesses of multi degrees of freedom heavy industrial robots. They are based on a locked link joint procedure obtained with an end-effector fixed to the environment. The first method
JUBIEN, Anthony   +5 more
core   +1 more source

Effect of matrix stiffness on osteoblast functionalization [PDF]

open access: yesCell Proliferation, 2017
AbstractObjectivesStiffness of bone tissue differs response to its physiological or pathological status, such as osteoporosis or osteosclerosis. Consequently, the function of cells residing in bone tissue including osteoblasts (OBs), osteoclasts and osteocytes will be affected.
Tao Zhang   +8 more
openaire   +2 more sources

Polydatin attenuates tubulointerstitial fibrosis in diabetic kidney disease by inhibiting YAP expression and nuclear translocation

open access: yesFrontiers in Physiology, 2022
The activation of Yes-associated protein (YAP) pathway is mutually causal with the increase of extracellular matrix (ECM) stiffness. Polydatin (PD) has been proved to have anti-fibrosis effect in diabetic kidney disease (DKD), but it is still a mystery ...
Manlin He   +8 more
doaj   +1 more source

Matrix Stiffness and Colorectal Cancer.

open access: yesOncoTargets and therapy, 2020
In recent years, a growing consensus is emerging that the mechanical microenvironment of tumors is far more critical in the onset of tumor, tumor progression, invasion, and metastasis. Matrix stiffness, one of the sources of mechanical stimulation, affects tumor cells as well as non-tumor cells in multiple different molecular signaling pathways in ...
Liu,Chongshun, Pei,Haiping, Tan,Fengbo
openaire   +3 more sources

A simplified geometric stiffness in stability analysis of thin-walled structures by the finite element method

open access: yesInternational Journal of Naval Architecture and Ocean Engineering, 2012
Vibration analysis of a thin-walled structure can be performed with a consistent mass matrix determined by the shape functions of all degrees of freedom (d.o.f.) used for construction of conventional stiffness matrix, or with a lumped mass matrix.
Ivo Senjanović   +2 more
doaj   +1 more source

Extracellular Matrix Rigidities Regulate the Tricarboxylic Acid Cycle and Antibiotic Resistance of Three‐Dimensionally Confined Bacterial Microcolonies

open access: yesAdvanced Science, 2023
As a major cause of clinical chronic infection, microbial biofilms/microcolonies in host tissues essentially live in 3D‐constrained microenvironments, which potentially modulate their spatial self‐organization and morphodynamics.
Yiming Han   +7 more
doaj   +1 more source

A numerical study on impact and compression after impact behaviour of variable angle tow laminates [PDF]

open access: yes, 2013
Recent developments of variable angled tow (VAT) technology have indicated that variable stiffness composite laminates offer a strong potential for structural tailoring.
Dang, Thi D., Hallett, Stephen R.
core   +1 more source

Chemotherapy‐Enriched THBS2‐Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications

open access: yesAdvanced Science, 2021
The physical microenvironment is a critical mediator of tumor behavior. However, detailed biological and mechanistic insight is lacking. The present study reveals the role of chemotherapy‐enriched CD133+ liver cancer stem cells (CSCs) with THBS2 ...
Kai‐Yu Ng   +11 more
doaj   +1 more source

Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism

open access: yesFrontiers in Oncology, 2021
In recent years, in-depth studies have shown that extracellular matrix stiffness plays an important role in cell growth, proliferation, migration, immunity, malignant transformation, and apoptosis.
Heming Ge   +4 more
doaj   +1 more source

TRPV4 Plays a Role in Matrix Stiffness-Induced Macrophage Polarization

open access: yesFrontiers in Immunology, 2020
Phenotypic polarization of macrophages is deemed essential in innate immunity and various pathophysiological conditions. We have now determined key aspects of the molecular mechanism by which mechanical cues regulate macrophage polarization. We show that
Bidisha Dutta   +2 more
doaj   +1 more source

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