Results 101 to 110 of about 132,623 (304)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Expression, purification and characterization of the HIV-1 coreceptor CCR5 and its ligand RANTES and high-pressure NMR investigation of hydrogen bonds in biomolecules [PDF]

open access: yes, 2010
Nuclear magnetic resonance spectroscopy is a very versatile technique for the investigation of biomolecular structures and dynamics. In this thesis, solution and solid state NMR methods have been applied to study a membrane protein and its interactions ...
Nisius, Lydia
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

The Coupled Manifold*

open access: yesJournal of the Atmospheric Sciences, 2005
Abstract A new method is presented to detect the portion of variability connected between two climatic fields. The method is a realization of the Procrustes problem, and it is a generalization of methods for analysis of variance such as the singular value decomposition (SVD) or canonical correlation analysis (CCA).
Navarra A, Tribbia J
openaire   +3 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Measurement of the WW cross section in √s = 7 TeV pp collisions with the ATLAS detector and limits on anomalous gauge couplings [PDF]

open access: yes, 2012
This Letter reports a measurement of the WW production cross section in √ s = 7 TeV pp collisions using data corresponding to an integrated luminosity of 1.02 fb−1 collected with the ATLAS detector.
Alessandria, F   +999 more
core   +3 more sources

Minimal flavor violation with axion-like particles

open access: yesJournal of High Energy Physics, 2017
We revisit the flavor-changing processes involving an axion-like particle (ALP) in the context of generic ALP effective lagrangian with a discussion of possible UV completions providing the origin of the relevant bare ALP couplings.
Kiwoon Choi   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Unexpectedly Large Couplings Between Orthogonal Units in Anthraquinone Polymers [PDF]

open access: yes, 2019
Directly linked polyanthraquinones have relatively large electronic couplings between charge-localized states despite near-orthogonality of the monomer units.
Piotr de Silva   +7 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

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