Results 131 to 140 of about 4,783,756 (301)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Ensayos Pedagógicos, 2009 The Tourist Industry has had a great development in the last ten tears in Costa Rica. This country has many special attractive destinations for foreigners that surpass a million and a halt annually. The province of Guanacaste, one of the biggest and more
Lucía Svetlana Villanueva Monge
doaj
Applying MOOCocracy learning culture themes to improve digital course design and online learner engagement. [PDF]
Educ Technol Res Dev, 2021 Akinkuolie B, Shortt M.
europepmc +1 more source
A Learning Design Studio in Mobile Learning
, 2012 Mobile learning is a young and vibrant field of research and practice. Teaching a university course on mobile learning is a challenge: how do you connect the theories and case studies to students’ experience, and make them relevant for their educational ...
Mogilevsky, Orit, Mor, Yishay
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
STUDENT THINKING WHEN STUDYING SCIENCE‐AND‐RELIGION
Zygon, 2009 Thirteen theology/religious studies students were interviewed while studying science‐and‐religion courses at four different institutions of higher education in the United Kingdom.
doaj +2 more sources
Empowering International Students by Embedding Formative Experience in Course Design [PDF]
No abstract ...
Elliot, Dely L.
core
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source