Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Classification of Features across Five CURE Networks Reveals Opportunities to Improve Course Design, Instruction, and Equity. [PDF]
J Microbiol Biol Educ, 2023 Burmeister AR, Bauer M, Graham MJ.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Industrial Course Bulletin (Vol. 2, No. 1), January 1924
, 1924 The industrial Course Newsletter was a newsletter issued by the Industrial Course of the International YMCA College, Springfield College. It ran from January 1923 to July 1924.
Industrial Course, International YMCA College
core +1 more source
Industrial Course Newsletter (Vol. 1, No. 3), July 1923
, 1923 The industrial Course Newsletter was a newsletter issued by the Industrial Course of the International YMCA College, Springfield College. It ran from January 1923 to July 1924.
Industrial Course, International YMCA College
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A mixed-methods study of the effectiveness and perceptions of a course design institute for health science educators. [PDF]
BMC Med Educ, 2022 Speer J +5 more
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Development of Simulation Based Machine Design course
, 2018 While the traditional product design method emphasizes the structure and the documentation of the design work, simulation based design can add more value to the design process by using for example multi-body, thermal or strength analysis. These tools are
Kiviluoma, Panu, Jaakma, Kaur
core
Interactive Course Design and Development for Cognitively Inspired Distance International Chinese Education. [PDF]
Comput Intell Neurosci, 2022 Zhang Q.
europepmc +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source