Results 111 to 120 of about 13,875 (179)

Navigating Challenges in Mass Spectrometry Analysis of Endogenous and Synthetic Protein Modifications. [PDF]

Biomolecules
Hanson CM, Bai DL, Marto JA.
europepmc   +1 more source

Structural Basis and Inhibitor Development of SARS-CoV-2 Papain-like Protease. [PDF]

Molecules
Wang J, Xu Y, Yang Y, Zhang B, Chen S, Li Z, Zhu H, Yang H, Wang H, Zhou Y, Cao P, Zhai B, Gong Y.   +12 more
europepmc   +1 more source

Artificial intelligence in drug discovery from advanced molecular representation to pipeline applications. [PDF]

Front Bioinform
Zhou X, Tao W.
europepmc   +1 more source

Disrupting the Undruggable: Emerging Modalities for Targeting Protein-Protein Interactions in Oncology. [PDF]

Biology (Basel)
El-Tanani M, Rabbani SA, Wali AF, El-Tanani Y, Sharma S.   +4 more
europepmc   +1 more source

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, EarlyView.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Enrichment-Free, Targeted Covalent Drug Discovery in Live Cells. [PDF]

ACS Chem Biol
Dong KD, Yu Q, Yang K, Wong BJ, Yue H, Fu S, Whitehouse RL, Fischer ES, Gygi SP.   +8 more
europepmc   +1 more source

Covalent Fragment-Based Drug Discovery: Mechanistic Approaches for Target Engagement and Reactivity Profiling

openaire   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Chemical proteomics reveals sinomenine's anti-inflammatory mechanism through serum protein covalent modification. [PDF]

Chin Med
Liu M, Zheng Z, Zhang Y, Bian X, Zhuo Y, Wu HY, Wu JL, Li N.   +7 more
europepmc   +1 more source

Antiviral drug discovery and development: challenges and future directions. [PDF]

Signal Transduct Target Ther
Du S, Hu X, Li P, Xu S, Kim M, Liu X, Zhan P.   +6 more
europepmc   +1 more source