Results 131 to 140 of about 13,875 (179)

Discovery of a First-in-Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity. [PDF]

Angew Chem Int Ed Engl
Qu Z, Meke FN, Zhang Z, Krabill AD, Muli CS, Jassim BA, Dong J, Nguyen QD, Bai Y, Li J, Miao Y, Asadi B, Johnson LM, Miao J, Trader DJ, Tao WA, Zhang ZY.   +16 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Frags2Drugs: A Novel In Silico Fragment-Based Approach to the Discovery of Kinase Inhibitors. [PDF]

Pharmaceuticals (Basel)
Peyrat G, Bournez C, Krezel P, Gally JM, Bourg S, Aci-Sèche S, Bonnet P.   +6 more
europepmc   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Next-generation Janus kinase inhibitors: Integrating synthetic innovation, structural biology, and computational design for precision drug discovery. [PDF]

Pharm Sci Adv
Karunakar KK, Cheriyan BV, Philiph S, Shanmugam RK, Sree J.   +4 more
europepmc   +1 more source

Bacterial backpacks for targeted delivery of piezoelectric nanoparticles to enhance sonodynamic immunotherapy

BMEMat, EarlyView.
Leveraging bacterial hypoxia targeting, KBTO NPs accumulate at the tumor site. Under the ultrasound irradiation, KBTO NPs produce reactive oxygen species to kill tumor cells and eliminate bacteria, preventing overgrowth and inflammation. The lysed bacteria act as antigens to trigger antitumor immunity and further enhanced by the immune checkpoint ...
Chongyang Liu, Haohui Zhu, Huaibin Yu, Xijun Zhang, Zhiqin Lei, Wenjing Xu, Xinyu Zhao, Ming Wu, Long Yang, Juanjuan Liu, Zhengbao Zha, Xinghui Si, Jianjun Yuan   +12 more
wiley   +1 more source

Exploring Novel E3 Ligases and Neosubstrates for Molecular Glue Degraders and Therapeutic Applications in Cancer. [PDF]

Oncol Res
Jang JH, Kim JY, Lee TJ.
europepmc   +1 more source

Mass Production of Waste PVC‐Mediated Bamboo‐Derived Hard Carbon for Ultra‐Long Life Sodium Storage

Carbon Energy, EarlyView.
By a scalable PVC‐mediated bifunctional strategy, pre‐carbonized micrometer bamboo powder is converted into a functionally partitioned hard carbon anode with distinct domains. Featuring abundant internal closed pores and surface sp2‐enriched graphitic regions, this anode delivers exceptional high‐rate long‐cycle stability, retaining 93% capacity after ...
Wenjing Xu, Zhangliu Tian, Meng Wang, Song Liang, Yueyang Wang, YuSha Gao, Yinjie Wan, Ce Zhou, Yue Tan, Le Wu, Fuqiang Huang   +10 more
wiley   +1 more source

From Serendipity to Strategy: Rationalizing Molecular Glue Discovery and Proximity-Induced Pharmacology through Chemical Biology. [PDF]

J Am Chem Soc
Gray JL, Xiao Z, Rogga VV, Zhang X, Tate EW.   +4 more
europepmc   +1 more source

In Vitro Activity of Citrus IntegroPectin Against Breast Cancer and Colon Cancer

ChemFoodChem, EarlyView.
Image shows microscopic photographs of MCF‐7 cells in the presence of lemon, red orange, and sweet orange IntegroPectin bioconjugates at 0.5 or 1.0 mg/mL concentration after 24 h next to a photograph of MCF‐7 cells as such (control). ABSTRACT We investigate the ability of IntegroPectin bioconjugates obtained via acoustic cavitation of lemon, red orange,
Claudia D'Anna, Caterina Di Sano, Giovanna Li Petri, Giuseppe Angellotti, Rosaria Ciriminna, Mario Pagliaro   +5 more
wiley   +1 more source