Results 151 to 160 of about 13,875 (179)

Modular Vinyl Phosphonamidates for Cysteine-Directed Protein Targeting. [PDF]

J Am Chem Soc
Stieger CE, Völkel C, Bertelsen MB, Lisurek M, Arafiles JVV, Franke J, Crocker L, Schuppe K, Lim Y, Groneberg C, Christmann M, Sun H, Hackenberger CPR.   +12 more
europepmc   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

The covalent docking software landscape: features and applications in drug design. [PDF]

Brief Bioinform
Singh N, Vayer P, Villoutreix BO.
europepmc   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

Black-box data: a new paradigm for biomedicine in the AI era. [PDF]

Chem Sci
Naef L, Bronstein M.
europepmc   +1 more source

Crystallographic fragment screening supports tool compound discovery and reveals conformational flexibility in human deoxyhypusine synthase. [PDF]

Commun Chem
Wilk P, Wątor-Wilk E, Muszak D, Kochanowski P, Krojer T, Grudnik P.   +5 more
europepmc   +1 more source

Covalent Targeting of Histidine Residues: A Ligand-First Approach. [PDF]

J Med Chem
Alboreggia G, Atienza EL, Muzzarelli K, Assar Z, Pellecchia M.   +4 more
europepmc   +1 more source

Quantum computing applications in drug discovery. [PDF]

Brief Bioinform
Li J, Wei L, Tong HHY, Zou Q.
europepmc   +1 more source

Stabilization of Native Protein-Protein Interactions with Molecular Glues: A 14-3-3 Case Study. [PDF]

Acc Chem Res
Konstantinidou M, Virta JM, Arkin MR.
europepmc   +1 more source

Quantum Mechanics in Drug Discovery: A Comprehensive Review of Methods, Applications, and Future Directions. [PDF]

Int J Mol Sci
Niazi SK.
europepmc   +1 more source