Results 61 to 70 of about 392,552 (294)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Metal-Based Drug–DNA Interactions and Analytical Determination Methods
MoleculesDNA structure has many potential places where endogenous compounds and xenobiotics can bind. Therefore, xenobiotics bind along the sites of the nucleic acid with the aim of changing its structure, its genetic message, and, implicitly, its functions ...
Adriana Corina Hangan +5 more
doaj +1 more source
COVALENCY EFFECTS IN HYPERFINE INTERACTIONS
Le Journal de Physique Colloques, 1974 The effects of covalency and overlap distortion on the spin and charge densities in mainly ionic materials are discussed and related to the hyperfine interactions. A linear combination of atomic orbitals is used although expansions and contractions of the wave functions relative to the free ion wave functions are also considered.
Sawatzky, G., van Der Woude, F.
openaire +2 more sources
The surface site interaction point approach to non-covalent interactions
Chemical Society Reviews, 2022 Non-covalent interactions are described using the SSIPs. Simple rules of thumb for predicting binding constants for any functional group interaction in any solvent are described, as well as general treatments of molecular properties like partition.
Storer, Maria Chiara +1 more
openaire +2 more sources
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Food Chemistry: XImproving anthocyanin stability is a major challenge for the food industry. Studies have revealed that the interaction with pectin through non-covalent bonds can improve the anthocyanin stability, thus showing the potential to alleviate the above ...
Chenyang Shi +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
MoleculesThe SARS-CoV-2 main protease (Mpro), essential for viral replication, remains a prime target for antiviral drug design against COVID-19 and related coronaviruses.
Adedapo Olosunde, Xiche Hu
doaj +1 more source
Deciphering the nature of ion-graphene interaction
Physical Review Research, 2020 Ion-specific interactions with materials are important for the design of ion-based energy and information devices, which are studied here with a focus on alkali-earth-metal and transition-metal ions in the context of carbon nanofluidics.
Ke Zhou, Zhiping Xu
doaj +1 more source
, 1999 Formation of clusters of interstitial carbon atoms between the surface and second atomic layers of graphite is demonstrated by means of molecular dynamics simulations.
Bolse +28 more
core +1 more source