Results 61 to 70 of about 3,934,989 (303)
Three dimensional protein assemblies directed by orthogonal non covalent interactions [PDF]
, 2016 In this report, an orthogonal non covalent interaction strategy based on specific recognition between sugar and protein, and host guest interaction, was employed to construct artificial three dimensional 3D protein assemblies in the ...
Yang, Guang. +6 more
core +1 more source
, 2023 We provide raw data associated with the manuscript "Large 31P-NMR enhancements in liquid state dynamic nuclear polarization through radical/target molecule non-covalent interaction", DOI: https://doi.org/10.1039/d2cp04092a. A description of the uploaded
Levien, Marcel +3 more
core +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Metal-Based Drug–DNA Interactions and Analytical Determination Methods
MoleculesDNA structure has many potential places where endogenous compounds and xenobiotics can bind. Therefore, xenobiotics bind along the sites of the nucleic acid with the aim of changing its structure, its genetic message, and, implicitly, its functions ...
Adriana Corina Hangan +5 more
doaj +1 more source
Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors [PDF]
, 2021 Targeted covalent inhibitors have re-emerged as validated drugs to overcome acquired resistance in cancer treatment. Herein, by using a carbonyl boronic acid warhead, we report the structure-based design of BCR-ABL inhibitors via reversible covalent ...
Guanghui, Tang +16 more
core +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Food Chemistry: XImproving anthocyanin stability is a major challenge for the food industry. Studies have revealed that the interaction with pectin through non-covalent bonds can improve the anthocyanin stability, thus showing the potential to alleviate the above ...
Chenyang Shi +7 more
doaj +1 more source
The effect of non-covalent functionalization on the interaction energy of carbon nanotubes
, 2019 The Lennard-Jones potential function together with the continuous approximation is employed to determine the van der Waals interaction between two parallel cylindrical nanotubes. Here we determine the interaction energy between carbon nanotubes and those
Ruengrot, P. +3 more
core +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
MoleculesThe SARS-CoV-2 main protease (Mpro), essential for viral replication, remains a prime target for antiviral drug design against COVID-19 and related coronaviruses.
Adedapo Olosunde, Xiche Hu
doaj +1 more source