Results 201 to 210 of about 309,621 (292)

MntJULiP and Jutils: differential splicing analysis of RNA-seq data with covariates. [PDF]

NAR Genom Bioinform
Lui WW, Yang G, He Z, Florea L.
europepmc   +1 more source

Assessing the Relative Importance of Imaging and Serum Biomarkers in Capturing Disability, Cognitive Impairment, and Clinical Progression in Multiple Sclerosis

Advanced Science, EarlyView.
Using machine‐learning analyses in two independent multiple sclerosis cohorts, spinal cord atrophy and cortical degeneration emerged as key predictors of disability and progression independent of relapses. Deep gray matter damage further improved prediction, while serum biomarkers of brain damage provided complementary information, highlighting the ...
Alessandro Cagol, Pascal Benkert, Sabine Schaedelin, Mario Ocampo‐Pineda, Noemi Montobbio, Po‐Jui Lu, Batuhan Ayci, Antonia Wenger, Alfi Aran Shukur, Kornelius Kaim, Lester Melie‐Garcia, Matthias Weigel, Alessio Signori, Pasquale Calabrese, Ludwig Kappos, Maria Pia Sormani, Jens Kuhle, Cristina Granziera   +17 more
wiley   +1 more source

Integrating Population Approaches With Physiologically Based Pharmacokinetic Models: A Novel Framework for Parameter Estimation. [PDF]

CPT Pharmacometrics Syst Pharmacol
Teutonico D, Marchionni D, Lavielle M, Nguyen L.   +3 more
europepmc   +1 more source

Pre-analysis Plan for a Comparison of Matching and Black Box-based Covariate Adjustment

, 2018
Luke Keele, Dylan S. Small
openalex   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Adaptive Sparsening and Smoothing of the Treatment Model for Longitudinal Causal Inference Using Outcome-Adaptive LASSO and Marginal Fused LASSO. [PDF]

Stat Med
Schnitzer ME, Talbot D, Liu Y, Berger D, Wang G, O'Loughlin J, Sylvestre MP, Ertefaie A.   +7 more
europepmc   +1 more source

Application of two-part models and Cholesky decomposition to incorporate covariate-adjusted utilities in probabilistic cost-effectiveness models

, 2018
Arantzazu Arrospide, Juan Manuel Ramos-Goñi, Petros Pechlivanoglou, Javier Mar   +3 more
openalex   +1 more source

Hump‐Shaped Relationship Between Microbial Carbon Use‐Efficiency and Soil Organic Carbon in Alpine Grasslands

Advanced Science, EarlyView.
On the Qinghai–Tibetan Plateau, microbial carbon use efficiency (CUE) peaks at intermediate soil organic carbon levels and declines thereafter. In carbon‐rich soils, the formation of stable mineral‐associated organic carbon is decoupled from microbial CUE.
Yuting Wang, Yongneng Wei, Gangsheng Wang, Yang Ruan, Ling Li, Xiang Liu, Yunfeng Yang, Qirong Shen, Ning Ling   +8 more
wiley   +1 more source