Results 61 to 70 of about 1,621,757 (315)

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Coverage Watch

open access: yesVoices in Bioethics, 2014
You may not have noticed her byline, but chances are you’ve read, and groaned over, Elizabeth Rosenthal’s reporting on healthcare costs for the New York Times. In her “Paying Till It Hurts” series, Rosenthal reports on our national whack-a-mole game of controlling healthcare costs.
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Determinants of influenza non-vaccination among Canadian children: insights from a nationwide survey

open access: yesFrontiers in Public Health
BackgroundTo identify determinants influencing Canadian parents’ decision not to vaccinate their children aged 6 months to 17 years against seasonal influenza.MethodsData from the 2022 Childhood COVID-19 Immunization Coverage Survey, a national survey of
Abdallah Alami   +5 more
doaj   +1 more source

Coverage search in 3D

open access: yes2013 IEEE International Symposium on Safety, Security, and Rescue Robotics (SSRR), 2013
Searching with a sensor for objects and observing parts of a known environment efficiently is a fundamental problem in many real-world robotic applications such as household robots searching for objects, inspection robots searching for leaking pipelines, and rescue robots searching for survivors after a disaster.
Dornhege, Christian   +2 more
openaire   +3 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Optimizing Stacked Ensemble Machine Learning Models for Accurate Wildfire Severity Mapping

open access: yesRemote Sensing
Wildfires are increasingly frequent and severe, posing substantial risks to ecosystems, communities, and infrastructure. Accurately mapping wildfire severity (WSM) using remote sensing and machine learning (ML) is critical for evaluating damages ...
Linh Nguyen Van, Giha Lee
doaj   +1 more source

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