Results 91 to 100 of about 299,239 (347)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Safety perspectives on presently considered drugs for the treatment of COVID‐19 [PDF]

British Journal of Pharmacology, 2020
Intense efforts are underway to evaluate potential therapeutic agents for the treatment of COVID‐19. In order to respond quickly to the crisis, the repurposing of existing drugs is the primary pharmacological strategy. Despite the urgent clinical need for these therapies, it is imperative to consider potential safety issues.
Penman, Sophie L., Kiy, Robyn T., Jensen, Rebecca L., Beoku‐Betts, Christopher, Alfirevic, Ana, Back, David, Khoo, Saye H., Owen, Andrew, Pirmohamed, Munir, Park, B. Kevin, Meng, Xiaoli, Goldring, Christopher E., Chadwick, Amy E.   +12 more
openaire   +5 more sources

The Interaction Between Pulmonary Fibrosis and COVID-19 and the Application of Related Anti-Fibrotic Drugs

Frontiers in Pharmacology, 2022
COVID-19 is a highly contagious respiratory disease, which mainly affects the lungs. Critically ill patients are easily complicated by cytokine storms, acute respiratory distress syndrome (ARDS), and respiratory failure, which seriously threaten their ...
Hao Shen, Hao Shen, Nu Zhang, Yuqing Liu, Xuerong Yang, Xuerong Yang, Yuanyuan He, Yuanyuan He, Qi Li, Qi Li, Xiaoyan Shen, Xiaoyan Shen, Yulian Zhu, Yong Yang, Yong Yang   +14 more
doaj   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Recommendations for the outpatient drug treatment of patients with COVID-19

Deutsches Ärzteblatt international, 2022
One of the purposes of outpatient treatment for COVID-19 patients is to prevent severe disease courses and hospitalization. There is a need for evidence-based recommendations to be applied in primary care and specialized outpatient settings.This guideline was developed on the basis of publications that were retrieved by a systematic search for ...
Kaduszkiewicz, Hanna, Kochen, Michael M., Kluge, Stefan, Malin, Jakob J., Weibel, Stephanie, Skoetz, Nicole   +5 more
openaire   +4 more sources

Available Drugs and Supplements for Rapid Deployment for Treatment of COVID-19 [PDF]

Journal of Molecular Cell Biology, 2020
Effective treatment for COVID-19 remains elusive, though urgently needed in the current pandemic. Repurposing marketed therapies may be an effective strategy for finding therapies quickly and recently in vitro and clinical testing of such therapies against SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) has skyrocketed.
Cicka, Danielle, Sukhatme, Vikas P
openaire   +3 more sources

What are the current anti-COVID-19 drugs? From traditional to smart molecular mechanisms

Virology Journal, 2023
Background Coronavirus disease 19 (COVID-19) is the disease caused by SARS-CoV-2, a highly infectious member of the coronavirus family, which emerged in December 2019 in “Wuhan, China”.
Sawsan Aboul-Fotouh, Ahmed Nageh Mahmoud, Esraa M. Elnahas, Mohamed Z. Habib, Sahar M. Abdelraouf   +4 more
doaj   +1 more source

Acute Kidney Injury Associated With Remdesivir: A Comprehensive Pharmacovigilance Analysis of COVID-19 Reports in FAERS

Frontiers in Pharmacology, 2022
Acute kidney injury (AKI) is a common complication among patients with the novel coronavirus (COVID-19). COVID-19 along with AKI usually resulted in a poor prognosis for those affected.
Bin Wu, Min Luo, Fengbo Wu, Zhiyao He, Yuwen Li, Ting Xu, Ting Xu   +6 more
doaj   +1 more source

SARS‐CoV‐2 Is Linked to Brain Volume Loss in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The impact of SARS‐CoV‐2 infection on brain and spinal cord pathology in patients with multiple sclerosis (pwMS) remains unclear. We aimed to describe changes in brain lesion activity and brain and spinal cord volumes following SARS‐CoV‐2 infection.
Tomas Uher, Dominika Stastna, Ingrid Menkyova, Vaclav Capek, Jiri Lindner, Petra Nytrova, Jan Krasensky, Eliza Varju, Miguel D'haeseleer, Eva Kubala Havrdova, Dana Horakova, Manuela Vaneckova, Niels Bergsland   +12 more
wiley   +1 more source

Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives

Frontiers in Pharmacology, 2020
The COVID-19 pandemic represents an unprecedented challenge for the researchers to offer safe, tolerable, and effective treatment strategies for its causative agent known as SARS-CoV-2.
Chandan Sarkar, Milon Mondal, Muhammad Torequl Islam, Muhammad Torequl Islam, Miquel Martorell, Miquel Martorell, Anca Oana Docea, Alfred Maroyi, Javad Sharifi-Rad, Daniela Calina   +9 more
doaj   +1 more source