Results 121 to 130 of about 248,209 (312)

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Effect of information provision on parental intention toward COVID-19 vaccination for children: a nationwide survey experiment

Scientific Reports
The reluctance of parents to vaccinate their children against COVID-19 was prevalent particularly when uncertainty over vaccination outcomes prevailed.
Hyunju Lee, Jung Hyun Park, Shinkyeong Kim, Sujin Seo, Minjung Lee, Myoungsoon You, Eun Hwa Choi, Geun-Yong Kwon, Jee Yeon Shin, Min-Ah Lee, Mi Jin Jeong, Young June Choe, Syngjoo Choi   +12 more
doaj   +1 more source

Beyond PEG: Emerging Polymer Lipid Alternatives for Lipid Nanoparticle (LNP) Formulations

Advanced Science, EarlyView.
This review discusses recent advances in PEG‐alternative LNP designs, including non‐PEG polymers, zwitterionic lipids, and polypeptides. It evaluates how surface‐engineering chemistry influences LNP formation and biological behavior, and highlights current limitations and opportunities of PEG‐alternative LNPs.
Zihnil A. I. Mazrad, Yi Ju, Stephen J. Kent, Colin W. Pouton, Kristian Kempe   +4 more
wiley   +1 more source

Acceptance and Practice to COVID-19 Vaccination Among Rural Population in Indonesia

Jurnal Ilmu Kesehatan Masyarakat
As one of the strategies to prevent and reduce the spread of COVID-19 since January 2021, the Indonesian Government has implemented a COVID-19 vaccination program.
Rifda Amalia Choirunnisa, Ede Surya Darmawan   +1 more
doaj   +1 more source

Ocular inflammatory events following COVID-19 vaccination: a multinational case series

Journal of Ophthalmic Inflammation and Infection, 2022
Background Inflammatory adverse events following COVID-19 vaccination are being reported amidst the growing concerns regarding vaccine’s immunogenicity and safety, especially in patients with pre-existing inflammatory conditions.
Ilaria Testi, Camilo Brandão-de-Resende, Rupesh Agrawal, Carlos Pavesio, for the COVID-19 Vaccination Ocular Inflammatory Events Study Group   +4 more
doaj   +1 more source

Lost and Found: Is Olfactory Recovery More Promising After COVID‐19 Than Other Causes, Even 2 Years Later?

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Olfactory dysfunction is a hallmark feature of COVID‐19, yet the potential for recovery with long‐standing COVID‐19‐related smell loss (CRSL) remains uncertain, particularly when treatment is initiated years later. This study evaluated olfactory outcomes in patients with CRSL compared with non‐COVID‐19‐related smell loss (non‐CRSL),
John W. Hunsicker, Mabel Berg, Nicolaus Knight, Jessica W. Grayson, Bradford A. Woodworth, Justin H. Turner, Do‐Yeon Cho   +6 more
wiley   +1 more source

The Impact of COVID-19 Vaccination and Infection on the Exacerbation of Myasthenia Gravis [PDF]

Objectives: Myasthenia Gravis (MG) is an autoimmune disorder that can exacerbate for various reasons, including vaccination and infection. This study aimed to investigate the safety of COVID-19 vaccines for MG patients, factors influencing MG ...
Haoran Liu, Ling Li, Yuting Jiang, Jianxin Han, Shengyao Su, Qi Wen, Yan Lu, Suobin Wang, Shu Zhang, Yuwei Da, Yanan Sun, Jingsi Wang, Min Xu, Li Di, Wenjia Zhu, Min Wang, Yaye Wang, Nairong Xie, Xinmei Wen, Hai Chen   +19 more
core   +1 more source

Age‐associated immune dysregulation links to disease severity in macrolide‐resistant Mycoplasma pneumoniae pneumonia: Insights from a comparative juvenile–adult mouse model

Animal Models and Experimental Medicine, EarlyView.
Macrolide‐resistant Mycoplasma pneumoniae (MRMP) infected both juvenile and adult mice, with results compared to normal juvenile mice. The findings revealed comparable bacterial loads between juvenile and adult mice, yet juvenile mice exhibited more severe lung damage and elevated levels of inflammatory cytokines.
Xuejun Li, Yudong Wang, Liyong Liu, Mengmeng Gong, Jinlong Wang, Yuqing Cao, Zhixin Sun, Fanliang Meng, Qiuyan Wang, Hongji Wu, Fei Zhao, Yan Ma, Yibai Xiong   +12 more
wiley   +1 more source

Refining a preclinical model of viral myocarditis in accordance with biotech standards

Animal Models and Experimental Medicine, EarlyView.
This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H. Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E. Camacho Londoño   +9 more
wiley   +1 more source