Results 101 to 110 of about 206,950 (307)

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

SARS-CoV-2 vaccine candidates in rapid development

Human Vaccines & Immunotherapeutics, 2021
The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still spreading globally. The scientific community is attempting to procure an effective treatment and prevention strategy for COVID-19.
Lifeng Li, Pengbo Guo, Xiaoman Zhang, Zhidan Yu, Wancun Zhang, Huiqing Sun   +5 more
doaj   +1 more source

Vaccine-Acquired SARS-CoV-2 Immunity versus Infection-Acquired Immunity: A Comparison of Three COVID-19 Vaccines

, 2022
Around the world, rollout of COVID-19 vaccines has been used as a strategy to end COVID-19-related restrictions and the pandemic. Several COVID-19 vaccine platforms have successfully protected against severe SARS-CoV-2 infection and subsequent deaths ...
Meron F. Tasissa, Mark J. Mulligan, Wilson, Jimmy P., Ramin Sedaghat Herati, Mulligan, Mark J., Samanovic, Marie I., Karmacharya, Trishala, Marie I. Samanovic, Aaron L. Oom, Gray-Gaillard, Sophie L., Michael Tuen, Tasissa, Meron F., Herati, Ramin Sedaghat, Shelby Goins, Goins, Shelby, Amber R. Cornelius, Oom, Aaron L., Cornelius, Amber R., Sophie L. Gray-Gaillard, Trishala Karmacharya, Tuen, Michael, Jimmy P. Wilson   +21 more
core   +1 more source

[COVID-19 vaccine safety].

Revista peruana de medicina experimental y salud publica, 2021
The development and production of safe and effective vaccines against coronavirus disease 2019 (COVID-19) provides hope for controlling the current pandemic. Adverse events following immunization are unwanted responses or unintended events that must be carefully monitored, as all vaccines, including those developed against SARS-CoV-2, are required to ...
Nataniel Aldo Chaparro Mérida, Dayany Moreno Samper, Alex Omar Franco Lacato   +2 more
openaire   +2 more sources

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Lost and Found: Is Olfactory Recovery More Promising After COVID‐19 Than Other Causes, Even 2 Years Later?

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Olfactory dysfunction is a hallmark feature of COVID‐19, yet the potential for recovery with long‐standing COVID‐19‐related smell loss (CRSL) remains uncertain, particularly when treatment is initiated years later. This study evaluated olfactory outcomes in patients with CRSL compared with non‐COVID‐19‐related smell loss (non‐CRSL),
John W. Hunsicker, Mabel Berg, Nicolaus Knight, Jessica W. Grayson, Bradford A. Woodworth, Justin H. Turner, Do‐Yeon Cho   +6 more
wiley   +1 more source

COVID-19 Vaccines: Current and Future Perspectives

, 2022
Currently available vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are highly effective but not able to keep the coronavirus disease 2019 (COVID-19) pandemic completely under control.
Andrea Corsonello, Luca Soraci, Giulia Soraci, Maria Elsa Gambuzza, Claudio Pulvirenti, Giovanni Rezza, Fabrizia Lattanzio, Annalisa Cozza, Filippo Luciani   +8 more
core   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Time for action: towards an intersectional gender approach to COVID-19 vaccine development and deployment that leaves no one behind

BMJ Global Health, 2021
Folake Olayinka, Sonali Kochhar, Shirin Heidari, Ruth Faden, Noni MacDonald, Tracey S Goodman   +5 more
doaj   +1 more source