Results 81 to 90 of about 5,155,633 (254)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

The COVID-19 Vaccines: Recent Development, Challenges and Prospects [PDF]

, 2021
The highly infectious coronavirus disease 2019 (COVID-19) associated with the pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to become a global pandemic.
Cheng Heng Pang, Ruiqi Wang, Yan, Yuxin, Xinyun Wu, Chong You, Edward Lester, Manickam, Sivakumar, Lester, Edward, Sivakumar Manickam, Yuxin Yan, Zhuoyi Lyu, Wu, Tao, Yoongxin Pang, Wang, Ruiqi, Lyu, Zhuoyi, Pang, Yoongxin, Pang, Cheng Heng, Haitao Zhao, Wu, Xinyun, You, Chong, Tao Wu, Zhao, Haitao   +21 more
core   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Efficacy of High Flow Nasal Cannula in the Treatment of Patients with COVID-19 with Acute Respiratory Distress Syndrome: Results of Single Centre Study in Vietnam

Pulmonary Therapy
Introduction Most hospitalized patients required invasive or non-invasive ventilation and High Flow Nasal Cannula (HFNC). Therefore, this study was conducted to describe the characteristics of patients with severe Coronavirus Disease—2019 (COVID-19 ...
Sy Duong-Quy, Duc Huynh-Truong-Anh, Tram Tang-Thi-Thao, Thu Nguyen-Ngoc-Phuong, Phung Hoang-Phi-Tuyet, Anh Nguyen-Tuan, Toi Nguyen-Van, Thanh Nguyen-Chi, Thanh Nguyen-Thi-Kim, Tien Nguyen-Quang, Thuy Tran-Ngoc-Anh, Nam Nguyen-Van-Hoai, Mai Do-Thi-Thu, Huong Hoang-Thi-Xuan, Thai Nguyen-Duy, Cong Nguyen-Hai, Tuan Huynh-Anh, Quan Vu-Tran-Thien, Khue Bui-Diem, Giang Nguyen-Mong, Hieu Nguyen-Lan, Giap Vu-Van, Phuong Phan-Thu, Long Nguyen-Viet, Chuong Nguyen-Hong, Sy Dinh-Ngoc, Trong Nguyen-Duc, Dung Truong-Viet, Thu Vo-Pham-Minh, Bao Le-Khac, Duc Nguyen-Hong, Timothy Craig, Vinh Nguyen-Nhu   +32 more
doaj   +1 more source

Fighting COVID 19 Vaccines Myths and Mis-Believes Among Medical Students, Egypt [PDF]

The Egyptian Family Medicine Journal
Background: Healthcare students (HCSs) are prospective clinical caregivers who should be informed about COVID- 19 immunization. Aim of the work: assess the mindset of medical students towards different approved COVID- 19 vaccines and predicting the ...
Almaza Salim, Fatma Rageh, Abdelmonem Elshabrawy, saad Shawki, Samar Ahmed   +4 more
doaj   +1 more source

COVID-19 Vaccine [PDF]

Endocrine Practice, 2021
Fernandes, Amanda, Chaudhari, Sonya, Jamil, Nadia, Gopalakrishnan, Geetha   +3 more
openaire   +2 more sources

Covid-19 vaccines for kids

New Scientist, 2021
Early trial results hint that vaccines could be safe for children, but how the virus behaves will determine their roll-out, reports Helen Thomson.
openaire   +2 more sources

Understanding COVID-19 Vaccines and Immunity [PDF]

, 2021
COVID-19 Vaccines are currently the talk of the world. The internet is full of memes on COVOD-19 vaccines - myths more than truths. In this commentary we further review some of the issues related to the success and failure of COVID-19 vaccines, and the ...
Sukumaran Anil, Lakshman ​ Samaranayake   +1 more
core   +1 more source

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Overview of COVID-19 vaccines [PDF]

Updated Aug. 24, 2022What You Need to Know\u2022 Different COVID-19 vaccines, which include boosters, are available in the United States. COVID-19 vaccines are approved for people of different ages, and on different schedules.\u2022 People who are ...

core   +2 more sources