Results 31 to 40 of about 5,076 (170)

Rat-to-Human Transmission of Cowpox Infection

Emerging Infectious Diseases, 2002
We isolated Cowpox virus (CPXV) from the ulcerative eyelid lesions of a 14-year-old girl, who had cared for a clinically ill wild rat that later died. CPXV isolated from the rat (Rattus norvegicus) showed complete homology with the girl’s virus. Our case
Tom F.W. Wolfs, Jaap A. Wagenaar, Hubert G.M. Niesters, Albert D.M.E. Osterhaus   +3 more
doaj   +1 more source

Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone [PDF]

Antiviral Research, 2012
Mitoxantrone, an FDA-approved therapeutic for the treatment of cancer and multiple sclerosis, was previously reported to exhibit antiviral activity against vaccinia virus. To determine whether this activity extends to other orthopoxviruses, mitoxantrone was tested against cowpox and monkeypox.
Altmann, Sharon E., Smith, Alvin L., Dyall, Julie, Johnson, Reed F., Dodd, Lori E., Jahrling, Peter B., Paragas, Jason, Blaney, Joseph E.   +7 more
openaire   +2 more sources

Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox

Viruses, 2021
Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial ...
Reed F. Johnson, Lauren A. Keith, Timothy K. Cooper, Srikanth Yellayi, Nicole M. Josleyn, Krisztina B. Janosko, James D. Pettitt, David Thomasson, Katie R. Hagen, Robin Gross, John G. Bernbaum, Debbie Douglas, Jeffrey Solomon, Mark Martinez, Kurt Cooper, Marisa St. Claire, Danny R. Ragland, Peter B. Jahrling, Jens H. Kuhn, Andrew E. Arai   +19 more
doaj   +1 more source

Necrotic Ulcerated Lesion in a Young Boy Caused by Cowpox Virus Infection

Case Reports in Dermatology, 2011
The case presented here points towards the fact that skin lesion observed with a cowpox virus is a rare event but should be considered more as the number of cases has increased in the last years. Cowpox virus (CPXV) belongs to the Poxviridae family.
Anne-Laure Favier, Olivier Flusin, Sébastien Lepreux, Hervé Fleury, Christine Labrèze, Aurélie Georges, Jean-Marc Crance, Franck Boralevi   +7 more
doaj   +1 more source

Skin lesions caused by Orthopoxvirus, cowpox - case report from Poland

Journal of Education, Health and Sport, 2021
Background:Despite the elimination of smallpox, other orthopoxviruses, including cowpox virus, still infect humans. Wild rodents are its natural reservoir.
Konrad Kania, Maria Kalicka, Tomasz Korzec, Przemyslaw Raczkiewicz, Monika Kuc   +4 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Viremia in human Cowpox virus infection

Journal of Clinical Virology, 2007
Several poxviruses can infect humans and cause diseases of varying severity. Besides the eradicated Variola virus that induced high mortality rates, numerous further human pathogenic orthopoxviruses are potentially fatal but generally cause less severe infections.
Nitsche, Andreas, Kurth, Andreas, Pauli, Georg   +2 more
openaire   +2 more sources

Machine Learning‐Augmented Loop‐Mediated Isothermal Amplification‐Enabled Point‐of‐Care for Mpox‐Specific Detection

Advanced Intelligent Systems, EarlyView.
A low‐cost, portable point‐of‐care platform for rapid Mpox detection using loop‐mediated isothermal amplification is reported. The device integrates fluorescence readout and mobile monitoring. A machine‐learning model analyzes temperature data and correlates thermal changes with DNA concentration, enabling sensitive and reliable molecular diagnosis in ...
Nazente Atceken, Ahmed Choukri Abdullah, Olgac Ozarslan, Ziya Yıldız, Savas Tasoglu   +4 more
wiley   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source