Results 91 to 100 of about 714,188 (330)

Expression of Cyclooxygenase Enhances Tumor Invasion and Metastasis in Human Gastric Carcinoma [PDF]

, 2004
Background: Expression of COX-2 in vitro has been shown to have a number of cellular effects including increasing proliferation, reducing apoptosis promoting angiogenesis, decreasing E-cadherin expression and increasing invasive/metastatic potential ...
Abdullah, M. (Murdani), Fujino, M. A. (Masayuki), Hardjodisastro, D. (Daldiyono), Kojima, Y. (Yuichiro), Otsuka, H. (Hiroyuki), Rani, A. A. (Abdul), Sato, T. (Tadashi)   +6 more
core   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

Antioxidant and Anti-inflammatory Activities of Salacca zalacca (Gaertn.) Peel Extract on Pb-induced Fibroblast Cells

Journal of Nature and Science of Medicine
Background: Salacca zalacca is a plant indigenous to Indonesia that consists of skin, pulp, and seed. The skin of S. zalacca, typically disposed of as waste, displays antioxidant and anti-inflammatory qualities.
Ermi Girsang, Chrismis Novalinda Ginting, I Nyoman Ehrich Lister, Fadhilah Haifa Zahiroh, Hanna Sari Widya Kusuma, Wahyu Widowati   +5 more
doaj   +1 more source

Investigation of the Relationship between COX-2 Expression, Clinicopathological Symptoms, and Prognosis of the Patients with Gastric Cancer [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2023
Introduction: The present study was designed to investigate the relationship between COX-2 gene expression, clinicopathological symptoms, and prognosis of patients with gastric cancer.
Abolfazl Hekmat-Shoar, AmirAli Moodi Ghalibaf, Ali Shamshirian, MohammadReza Abbaszadegan4, Bahram Memar, Mohammad Reza Motie   +5 more
doaj  

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Upregulation of PPAR-gamma activity inhibits cyclooxygenase 2 expression in cortical neurons with N-methyl-d-aspartic acid induced excitatory neurotoxicity

Biotechnology & Biotechnological Equipment, 2019
This study aimed to investigate the effect of upregulated peroxisome proliferator-activated receptor-gamma (PPAR-γ) activity on cyclooxygenase 2 (COX-2) expression and N-methyl-d-aspartic acid (NMDA)-induced excitatory neurotoxicity in primary cultured ...
Qi-Fang Weng, Guo-Bin Chen, Min-Guang Xu, Ru-Tao Long, Han Wang, Xiao-Ying Wang, Chao-Na Jiang, Xi-Nan Yi   +7 more
doaj   +1 more source

COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells. [PDF]

, 2018
The nucleus pulposus (NP) of intervertebral discs experiences dynamic changes in tissue osmolarity because of diurnal loading of the spine. TonEBP/NFAT5 is a transcription factor that is critical in osmoregulation as well as survival of NP cells in the ...
Chaiyamongkol, Weera, Choi, Hyowon, Doolittle, Alexandra C., Gogate, Shilpa S., Johnson, Zariel I., Risbud, Makarand V., Schoepflin, Zachary R., Shapiro, Irving M.   +7 more
core   +1 more source

Increased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients [PDF]

, 2005
Aim: To study the expression of cyclooxygenase-2 (COX-2) in human gastric cancer tissues and their paired adjacent mucosa, as well as mucosa from gastric antrum and corpus of the first-degree relatives of the recruited cancer patients.
Chu, JK, Cui, DS, Huo, XH, Qiao, L, Wang, MW, Yu, J, Zhang, JT, Zhu, ZL   +7 more
core   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Upregulation of Cytokines and Differentiation of Th17 and Treg by Dendritic Cells: Central Role of Prostaglandin E2 Induced by Mycobacterium bovis

Microorganisms, 2020
Mycobacterium bovis (M. bovis) is a zoonotic pathogen that causes bovine and human tuberculosis. Dendritic cells play a critical role in initiating and regulating immune responses by promoting antigen-specific T-cell activation.
Han Liu, Xuekai Xiong, Wenjun Zhai, Tingting Zhu, Xiaojie Zhu, Yifan Zhu, Yongchong Peng, Yongliang Zhang, Jieru Wang, Huanchun Chen, Yingyu Chen, Aizhen Guo   +11 more
doaj   +1 more source