Results 151 to 160 of about 714,188 (330)

Anti-allodynic effects of oral COX-2 selective inhibitor on postoperative pain in the rat [PDF]

, 2000
Tatsuo Yamamoto, Yoshihiko Sakashita, Natsuko Nozaki‐Taguchi   +2 more
openalex   +1 more source

Do COX-2 inhibitors worsen renal function? [PDF]

, 2007
No, COX-2 inhibitors, as a class, do not worsen renal function for those without renal disease. Celecoxib is the only COX-2 inhibitor available, and it is associated with a lower risk of renal dysfunction and hypertension when compared with controls ...
Jamieson, Barbara, Strickland, Carmen, Wall, Richard   +2 more
core  

Antimicrobial Titanium–Copper Alloys: The Role of Microstructure in Arc‐Melted Compositions

Advanced Engineering Materials, EarlyView.
Copper‐containing titanium alloys show promise in combating orthopedic implant infections. This study explores the influence of heat treatment on Ti‐11.5Cu and Ti‐33Cu alloys, revealing that larger Ti2Cu precipitates (≈5 μm) enhance antimicrobial efficacy through increased surface contact. Results suggest contact sterilization is the primary mechanism,
Daisy Rabbitt, Paraic O’Kelly, Victor M. Villapún, Luke N. Carter, Alexander J. Knowles, Sophie C. Cox   +5 more
wiley   +1 more source

A novel mode of action for COX‐2 inhibition: Targeting ATPase domain of HSP90 induces ubiquitin degradation of new client protein COX‐2

Clinical and Translational Medicine, 2022
Man Zhang, Jing Cui, Fukui Shen, Lili Ye, Chuanjing Cheng, Yang Li, Qiuyang Zhang, Lin Niu, Yuanyuan Hou, Gang Bai   +9 more
doaj   +1 more source

Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2

, 1999
Brendan McAdam, Francesca Catella-Lawson, Issam A. Mardini, Shiv Kapoor, John A. Lawson, Garret A. FitzGerald   +5 more
openalex   +1 more source

Detection of EGFR and COX-2 Expression by Immunohistochemical Method on a Tissue Microarray Section in Lung Cancer and Biological Significance [PDF]

, 2010
Background and objective Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2), which can regulate growth, invasion and metastasis of tumor through relevant signaling pathway, have been detected in a variety of solid tumors.
Congzhong ZHU, Juan LIU, Xinyun WANG
core  

High‐Temperature Oxidation of the CrFeNi Medium‐Entropy Alloy

Advanced Engineering Materials, EarlyView.
The oxidation behavior of equiatomic CrFeNi MEA is a key issue that determines this material's suitability for high‐temperature application. The understanding of long‐term behavior is even more crucial than short‐term corrosion effects. The alloy is exposed to synthetic air at 1000, 1050, and 1100 °C for 24, 100, and 1000 h and systematically compared ...
Anna Maria Manzoni, Wencke Mohring, Mike Schneider, Guillaume Laplanche, Sebastian Peter Hagen, Christiane Stephan‐Scherb   +5 more
wiley   +1 more source

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

Matrix Tropism Influences Endometriotic Cell Attachment Patterns

Advanced Functional Materials, EarlyView.
The influence of substrate stiffness and multicellular coculture on endometriotic cell attachment to extracellular matrix‐laden microarrayed islands is reported. This model investigates early endometriotic cell attachment, aiming to capture “lesion initiation events”.
Hannah S. Theriault, Hannah R.C. Kimmel, Alison C. Nunes, Allison L. Paxhia, Sarah Hashim, Kathryn B.H. Clancy, Gregory H. Underhill, Brendan A.C. Harley   +7 more
wiley   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source