Results 311 to 320 of about 714,188 (330)
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The safety of COX-2 inhibitors
Orvosi Hetilap, 2008A nemszteroid gyulladáscsökkentők (NSAID) a leggyakrabban alkalmazott gyógyszerek közé tartoznak világszerte. Az NSAID-ok súlyos emésztőszervi mellékhatásokat okozhatnak, a szerek a tápcsatorna bármely szakaszát károsíthatják. A ciklooxigenáz-2- (COX-2-) gátlók (coxibok) kifejlesztésétől változatlan gyulladáscsökkentő hatás mellett kedvezőbb ...
Zsolt Tulassay +2 more
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Free Radical Biology and Medicine, 2017
Cyclooxygenase-2 (COX-2), an inducible isoform responsible for high levels of prostaglandin (PG) production during inflammation and immune responses, mediate a variety of biological actions involved in vascular pathophysiology. COX-2 is induced by various stimuli, including proinflammatory cytokines, to result in PG synthesis associated with ...
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Cyclooxygenase-2 (COX-2), an inducible isoform responsible for high levels of prostaglandin (PG) production during inflammation and immune responses, mediate a variety of biological actions involved in vascular pathophysiology. COX-2 is induced by various stimuli, including proinflammatory cytokines, to result in PG synthesis associated with ...
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1995
The main target of non-steroidal anti-inflammatory drugs (NSAIDs) is prostaglandin G/H synthase (PGHS), also known as cyclooxygenase (COX), which exists as two isoforms. In order to evaluate the contributions of PGHS isoforms to physiological and pathological conditions and their sensitivity to inhibition by non-steroidal anti-inflammatory drugs, we ...
G. P. O’neill +17 more
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The main target of non-steroidal anti-inflammatory drugs (NSAIDs) is prostaglandin G/H synthase (PGHS), also known as cyclooxygenase (COX), which exists as two isoforms. In order to evaluate the contributions of PGHS isoforms to physiological and pathological conditions and their sensitivity to inhibition by non-steroidal anti-inflammatory drugs, we ...
G. P. O’neill +17 more
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Inflammation Research, 1998
The role of cyclooxygenase-2 (COX-2) in colorectal tumorigenesis in mice was studied by Oshima et al. to determine the effects of COX-2 gene knockouts and a new COX-2 inhibitor. In the study, heterozygous Apcdelta716 knockout mice, a mouse model of human familial adenomatous polyposis (FAP), were either crossed to COX-2 gene knockout mice, or fed chow ...
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The role of cyclooxygenase-2 (COX-2) in colorectal tumorigenesis in mice was studied by Oshima et al. to determine the effects of COX-2 gene knockouts and a new COX-2 inhibitor. In the study, heterozygous Apcdelta716 knockout mice, a mouse model of human familial adenomatous polyposis (FAP), were either crossed to COX-2 gene knockout mice, or fed chow ...
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Current Pharmaceutical Design, 2003
Metabolites of arachidonic acid participate in normal growth responses and in aberrant cellular growth and proliferation, including carcinogenesis. The key step in the conversion of free arachidonic acid to prostaglandins is catalyzed by the cyclooxygenase enzyme (COX). There are two COX enzymes, COX-1 and COX-2.
Randall W. Burt +2 more
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Metabolites of arachidonic acid participate in normal growth responses and in aberrant cellular growth and proliferation, including carcinogenesis. The key step in the conversion of free arachidonic acid to prostaglandins is catalyzed by the cyclooxygenase enzyme (COX). There are two COX enzymes, COX-1 and COX-2.
Randall W. Burt +2 more
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2004
Multiple epidemiological studies indicate that the use of aspirin and other NSAIDs are associated with reduced risk of malignancies especially in the digestive tract. In addition, another NSAID sulindac causes regression of colorectal adenomatous polyps in patients with familial adenomatous polyposis (FAP) [1, 2]. Recent studies suggest that COX-2 is a
Christianne J. Buskens +10 more
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Multiple epidemiological studies indicate that the use of aspirin and other NSAIDs are associated with reduced risk of malignancies especially in the digestive tract. In addition, another NSAID sulindac causes regression of colorectal adenomatous polyps in patients with familial adenomatous polyposis (FAP) [1, 2]. Recent studies suggest that COX-2 is a
Christianne J. Buskens +10 more
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2004
For over 3000 years various herbal medicines, such as extracts of willow bark, or dried leaves of myrtle or meadowsweet have been used with apparent anecdotal success for the treatment of the pain and swelling of inflammatory disease. By the middle of the nineteenth century the active constituent of these various herbal remedies was found to be ...
Jack Howard Botting, Regina M. Botting
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For over 3000 years various herbal medicines, such as extracts of willow bark, or dried leaves of myrtle or meadowsweet have been used with apparent anecdotal success for the treatment of the pain and swelling of inflammatory disease. By the middle of the nineteenth century the active constituent of these various herbal remedies was found to be ...
Jack Howard Botting, Regina M. Botting
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COX-2 Inhibitors and the Kidney
Hospital Practice, 2001Prostaglandins produced by the COX-2 isoform of cyclooxygenase may be important for renal function--and perhaps even more so in diseases that render the kidney highly prostaglandin-dependent. COX-2 inhibitors may thus have much the same renal risks that a standard NSAID does. Several clinical trials have already focused on the new drugs' renal effects.
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Biochemistry of Cyclooxygenase (COX)-2 Inhibitors and Molecular Pathology of COX-2 in Neoplasia
Critical Reviews in Clinical Laboratory Sciences, 2000Several types of human tumors overexpress cyclooxygenase (COX) -2 but not COX-1, and gene knockout transfection experiments demonstrate a central role of COX-2 in experimental tumorigenesis. COX-2 produces prostaglandins that inhibit apoptosis and stimulate angiogenesis and invasiveness.
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