Results 61 to 70 of about 714,188 (330)

In Silico Anti-Inflammatory Activity Evaluation from Usnea misaminensis through Molecular Docking Approach

Chemistry and Materials, 2022
Usnea misaminensis is an epiphytic medicinal plant from Indonesia that has several benefits, one of which is as an anti-inflammatory. This study aims to predict the ability of three compounds from Usnea misaminensis to inhibit the COX-2 enzyme as a ...
Ranggaweny Al-Ghani, Wita Putri Nirwani, Tria Nurwina Novianti, Adani Ghina Puspita Sari   +3 more
doaj   +1 more source

Cyclooxygenase-2 Overexpression is Common in Serrated and Non-Serrated Colorectal Adenoma, but Uncommon in Hyperplastic Polyp and Sessile Serrated Polyp/Adenoma [PDF]

, 2011
Background: Cyclooxygenase-2 (COX-2, PTGS2) plays an important role in colorectal carcinogenesis. COX-2 overexpression in colorectal cancer is inversely associated with microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP ...
Chan, Andrew Tan, Fuchs, Charles Stewart, Glickman, Jonathan Neil, Kawasaki, Takako, Kirkner, Gregory J, Mino-Kenudson, Mari, Nosho, Katsuhiko, Ogino, Shuji, Ohnishi, Mutsuko, Suemoto, Yuko   +9 more
core   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Thinking outside the box about COX-1 in Alzheimer's disease

Neurobiology of Disease, 2010
This article from Coma et al. shows that a salicylic acid derivative Triflusal, a platelet aggregation inhibitor and irreversible inhibitor of COX-1, can correct defects in axonal curvature and cognition in an AD transgenic mouse model (Tg2576) (Coma et ...
Sally A. Frautschy
doaj   +1 more source

ANTI-INFLAMMATORY ACTIVITY OF STEM BARK DICHLOROMETHANE FRACTION Syzygium samarangense EXTRACT AS COX-2 INHIBITOR: A BIOINFORMATICS APPROACH

Jurnal Kimia Riset, 2022
Syzygium samarangense is a plant that is rich in flavonoid compounds. Previous research revealed that the dichloromethane fraction from the stem bark extract contained four bioactive compounds, namely, pinocembrin, uvangoletin, stercurensin, and ...
Ahmad Misbakhus Sururi, M. Raihan, Elvira Ratna Aisa, Frisca Nadya Safitri, Irene Cornelia Constaty, Tukiran   +5 more
doaj   +1 more source

COX-2 in synovial tissues

Osteoarthritis and Cartilage, 1999
Prostaglandins (PGs) are important mediators of acute and chronic inflammation. The production of PGs in synovial tissues is catalyzed by an enzyme cascade that includes phospholipase A(2)s (PLA(2)s), cyclooxygenases (COXs), and terminal PG synthases. There are two isoforms of COX expressed in synovial tissues.
openaire   +3 more sources

Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney [PDF]

, 2015
BACKGROUND: The role of cyclooxygenase(COX)-1 and COX-2 in the saluretic and renin-angiotensin responses to loop diuretics in the cat is unknown. We propose in vivo characterisation of isoform roles in a furosemide model by administering non-steroidal ...
A Hayes, B Mann, B Rose, B Rose, B Rose, CM Hao, DA Heller, DO Stichtenoth, F Catella-Lawson, F Nantel, G Giovanni, H Syme, H. Syme, J Hippisley-Cox, J Peti-Peterdi, J. Elliott, J. N. King, JA Jakobsen, K Schumacher, K. Smith, KA Kirchner, KL Therland, KN Khan, KN Khan, L Pelligand, L Pelligand, L. Pelligand, M Komhoff, M Meskell, M Sabbatini, N. Suemanotham, P. Lees, PA Friedman, RC Harris, RC Harris, RE Jepson, S Yu, V Campean, V Sreenivasan, VB Schmid, W. Seewald, WA Corsini, XR He   +42 more
core   +2 more sources

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells [PDF]

, 2012
Cyclic AMP (cAMP) is the archetypal smooth muscle relaxant, mediating the effects of many hormones and drugs. However, recently PGI2, acting via cAMP/PKA, was found to increase contraction-associated protein expression in myometrial cells and to promote ...
Amsen, Blumenfeld, Cao, Faour, Fetalvero, Goldenberg, Jung, Kaminski, Kirtikara, Klein, Landau, Martin, Matsuura, Mehats, Meloni, Minguet, Mohan, Olson, Oyesanya, Schmitz, Schroer, Simhan, Simpkin, Slater, Sooranna, Sparey, Ster, Streicher, Subbaramaiah, Sun, Wadhwa, Wu, Xu, Yaqub, Yin, Zakar   +35 more
core   +2 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source