Results 241 to 250 of about 26,709,678 (285)

Non‐Invasively Quantitative Raman Imaging for Calculation of Lymphatic Transport Kinetics of Micelles in Mice

Advanced Science, EarlyView.
Non‐invasively quantitative Raman imaging with stacking‐induced charge transfer‐enhanced Raman scattering (SICTERS) enables accurate measurement of concentrations and pharmacokinetic modeling of lymphatic transport of micelles in mice. This platform allows dynamic analysis of nanoparticle transport and underpins the design of effective lymph node ...
Yunlu Li, Hongzheng Lin, Sheng Yu, Yunhui Liao, Teng Huang, Zeyu Xiao, Wei Lu   +6 more
wiley   +1 more source

New pyrazole-pyridazine hybrids as selective COX-2 inhibitors: design, synthesis, molecular docking, <i>in silico</i> studies and investigation of their anti-inflammatory potential by evaluation of TNF-α, IL-6, PGE-2 and NO in LPS-induced RAW264.7 macrophages. [PDF]

RSC Med Chem
Osman EO, Khalil NA, Magdy A, El-Dash Y.
europepmc   +1 more source

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Selective COX-2 inhibitors as anticancer agents: a patent review (2014-2018)

Expert Opinion on Therapeutic Patents, 2019
Introduction: COX-2 is a key enzyme in the process of prostaglandins (PGs) synthesis. The products of this enzyme could play a major role as the mediators of the inflammatory response and some other medical states such as cancer. The design and synthesis
Afshin Zarghi
exaly   +2 more sources

Emerging COX-2 inhibitors-based nanotherapeutics for cancer diagnosis and treatment

Biomaterials
Increasing evidence has showed that tumorigenesis is closely linked to inflammation, regulated by multiple signaling pathways. Among these, the cyclooxygenase-2/prostaglandin E2 (COX-2/PGE2) axis plays a crucial role in the progression of both ...
Yongjun Wang, Baoyue Zhang, Ruiping Huang   +2 more
exaly   +2 more sources

COX-1 and COX-2 inhibitors

Bailliere's Best Practice and Research in Clinical Gastroenterology, 2001
C. Hawkey
exaly   +2 more sources

Natural COX-2 inhibitors as promising anti-inflammatory agents: an update.

Current Medicinal Chemistry, 2020
COX-2, a key enzyme that catalyzed the rate-limiting steps in the conversion of arachidonic acid to prostaglandins, played a pivotal role in inflammatory process.
Jiahua Cui, J. Jia
semanticscholar   +1 more source

Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: A review.

Life Science, 2020
Initially, the selective COX-2 inhibitors were developed as safer alternatives to the conventional NSAIDs, but later on, most of them were withdrawn from the market due to the risk of heart attack and stroke.
M. Arora, S. Choudhary, P. Singh, B. Sapra, O. Silakari   +4 more
semanticscholar   +1 more source

Recent advancement in the discovery and development of COX-2 inhibitors: Insight into biological activities and SAR studies (2008-2019).

Bioorganic chemistry (Print), 2019
Cyclooxygenase-2 is a very important physiological enzyme playing key roles in various biological functions especially in the mechanism of pain and inflammation, among other roles, making it a molecule of high interest to the pharmaceutical community as ...
V. Sharma, Parth Bhatia, O. Alam, Mohd Javed Naim, Farah Nawaz, Aadil Ahmad Sheikh, M. Jha   +6 more
semanticscholar   +1 more source

Identification of COX-2 inhibitors via structure-based virtual screening and molecular dynamics simulation.

Journal of Molecular Graphics and Modelling, 2018
In an attempt to identify potential COX-2 inhibitors, a multi-step virtual screening strategy was performed on a series of compounds. For this purpose, ZINC database was screened on the basis of 50% structural similarity with celecoxib and indomethacin ...
N. Razzaghi-Asl, Sahar Mirzayi, K. Mahnam, Saghi Sepehri   +3 more
semanticscholar   +1 more source

Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships

Iranian journal of pharmaceutical research, 2011
Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs).
A. Zarghi, S. Arfaei
semanticscholar   +1 more source