Results 71 to 80 of about 26,709,678 (285)
Dual acting COX/LOX nonsteroidal anti-inflammatory drugs versus traditional COX-2 inhibitors
Current Issues in Pharmacy and Medical Sciences, 2010 Dual COX/LOX inhibitors, by acting on the two major arachidonic acid metabolic pathways – cyclooxygenase and lipooxygenase, possess a wide range of anti-inflammatory activity.
Iryna Fomenko +2 more
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li +11 more
wiley +1 more source
Postoperative Pain, COX-2 Inhibitors
, 2013 COX-2 inhibitors are anti-inflammatory analgesics that act by specific inhibition of one of the isoenzymes involved in prostaglandin synthesis, cyclooxygenase 2 (COX-2). These drugs were developed as an alternative to traditional NSAIDs ( NSAIDs, Survey),
Colvin, Lesley A.; id_orcid +3 more
core +1 more source
Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang +4 more
wiley +1 more source
Selective COX-2 inhibitors: Present state
, 2017 This thesis has the objective of reviewing the current state of affairs for COX-2 inhibitors and to highlight the needs in dentistry as well as determining whether these drugs can be used as alternatives to the widely used NSAIDs ...
Patel, Jay
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian +6 more
wiley +1 more source
Design and Synthesis of Imidazopyrazolopyridines as Novel Selective COX-2 Inhibitors
Molecules, 2015 The usefulness of non-steroidal anti-inflammatory drugs (NSAIDs) is hampered by their gastrointestinal side effects. Non-selective cyclooxygenases inhibitors interfere with both COX-1 and COX-2 isozymes.
Mohamed G. Badrey +4 more
doaj +1 more source
Elucidating the Binding Behavior of Highly Potent COX-2 Selective Inhibitors
, 2012 Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the cyclooxygenase enzymes (COXs), and are widely used for the treatment of inflammation, pain, and cancers.
F. S. Di Leva +7 more
core
Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal +10 more
wiley +1 more source
Experimental and clinical pharmacology: COX-2 inhibitors
, 2000 There are two cyclo-oxygenase enzymes: COX-1 regulates physiological function in the gut and kidney, while COX-2 is induced in inflammation and repair. Selective COX-2 inhibitors are now available. In early clinical trials their efficacy in arthritis was
Brooks, Peter M.
core +1 more source