Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice [PDF]
BMC Neuroscience, 2009 Background Neuroinflammation contributes to the pathophysiology of acute CNS injury, including traumatic brain injury (TBI). Although prostaglandin lipid mediators of inflammation contribute to a variety of inflammatory responses, their importance in ...
Scheff Stephen W +3 more
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Endocrinological features and epileptic encephalopathy in COX deficiency due to SCO1 mutations: case series and review of literature [PDF]
Endocrine ConnectionsContext: Cytochrome C oxidase (COX) is the fourth component of the respiratory chain and is located within the internal membrane of mitochondria.
Alessandro Barbato +15 more
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Prognostic associations of vitamin D deficiency with disease severity, survival, and complications in alcohol-related liver disease [PDF]
Frontiers in MedicineBackgroundVitamin D deficiency has been associated with adverse outcomes in various chronic diseases, and its relevance in alcohol-related liver disease (ALD) has attracted increasing attention. This study aimed to evaluate the prognostic significance of
Qiufeng He +6 more
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Pharmacologic Inhibition of COX-1 and COX-2 in Influenza A Viral Infection in Mice [PDF]
PLoS ONE, 2010 We previously demonstrated that cyclooxygenase (COX)-1 deficiency results in greater morbidity and inflammation, whereas COX-2 deficiency leads to reduced morbidity, inflammation and mortality in influenza infected mice.We investigated the effects of COX-
Darryl C Zeldin
exaly +2 more sources
Cells, 2022 Cyclooxygenase-2 (COX-2) plays a critical role in regulating innate immunity and metabolism by producing prostaglandins (PGs) and other lipid mediators. However, the implication of adipose COX-2 in obesity remains largely unknown.
Chunqing Wang, Xing Zhang, Liping Luo
exaly +3 more sources
Mitochondrial Cytochrome c Oxidase Defects Alter Cellular Homeostasis of Transition Metals
Frontiers in Cell and Developmental Biology, 2022 The redox activity of cytochrome c oxidase (COX), the terminal oxidase of the mitochondrial respiratory chain (MRC), depends on the incorporation of iron and copper into its catalytic centers.
Michele Brischigliaro +11 more
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Construction of a TCM and Western combination model for prognostic evaluation of chronic heart failure based on TCM syndrome elements and machine learning [PDF]
Jichu yixue yu linchuang, 2022 Objective To construct a prognostic model of chronic heart failure (CHF) by traditional Chinese medicine (TCM) syndrome elements by machine learning method.
FAN Jia-sai, DU Yi-fei, XU Jia-ying, CHEN Si-zhen, GAO Yong-hui, REN Jing-yi
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Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. [PDF]
, 2014 An inherited deficiency of the mitochondrial protein frataxin causes Friedreich's ataxia (FRDA); the mechanism by which this deficiency triggers neuro- and cardio-degeneration is unclear.
Cortopassi, Gino +5 more
core +4 more sources
Alterations of sirtuins in mitochondrial cytochrome c-oxidase deficiency. [PDF]
PLoS ONE, 2017 Sirtuins are NAD+ dependent deacetylases, which regulate mitochondrial energy metabolism as well as cellular response to stress. The NAD/NADH-system plays a crucial role in oxidative phosphorylation linking sirtuins and the mitochondrial respiratory ...
Arne Björn Potthast +3 more
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BMC Geriatrics, 2022 Background The association of vitamin D with all-cause mortality remains controversial and longitudinal evidence exploring the potential effects of change in vitamin D status is limited in the oldest old (aged ≥ 80 years old).
Jing Zeng +10 more
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