Results 191 to 200 of about 402,477 (353)
Advanced Science, EarlyView.This study develops an a red/far‐red light‐controlled iPSC‐based vaccines (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 for cancer immunotherapy. The RIVA preserves the multiple intrinsic tumor antigens of iPSCs and enables optogenetic control of the expression of the immune adjuvant type I interferon β under
Longliang Qiao +17 more
wiley +1 more source
Predictive determinants of overall survival among re-infected COVID-19 patients using the elastic-net regularized Cox proportional hazards model: a machine-learning algorithm. [PDF]
BMC Public Health, 2022 Ebrahimi V +6 more
europepmc +1 more source
Advanced Science, EarlyView.This study identifies fatty acid desaturase 2 (FADS2) as a key regulator linking polyunsaturated fatty acid (PUFA) metabolism to psoriatic inflammation. FADS2 deficiency impairs docosahexaenoic acid (DHA) biosynthesis, enhances NF‐κB signaling, and promotes neutrophil‐driven skin inflammation. PPARα transcriptionally activates FADS2, and its activation
Jiangluyi Cai +19 more
wiley +1 more source
Role of SLC16A10 in Psoriasis Through the Regulation of Arachidonic Acid Metabolism in Keratinocytes
Advanced Science, EarlyView.This study demonstrates that SLC16A10 plays a crucial role in psoriasis pathogenesis through arachidonic acid metabolism regulation in keratinocytes. Using multi‐omics analysis and experimental validation, researchers identify SLC16A10 as both a diagnostic biomarker and therapeutic target.
Jingyuan Yang +17 more
wiley +1 more source
Advanced Science, EarlyView.Neuromyelitis optica spectrum disorder (NMOSD) has distinct acute‐remitting courses but lacks biomarkers for predicting relapse. Recent studies found cuproptosis‐related genes affect its course, and a model built accordingly can predict relapse to aid intervention.
Peidong Liu +17 more
wiley +1 more source