Results 241 to 250 of about 402,477 (353)
Advanced Science, EarlyView.A molecular engineering strategy is developed to increase the stacking‐induced intermolecular charge transfer‐enhanced Raman scattering (SICTERS) intensity and photothermal conversion efficiency of electron donor‐acceptor‐donor (D–A–D) molecules. This approach enables to design SICTERS‐mediated photo‐theranostic agents for substrate‐free Raman image ...
Sheng Yu +9 more
wiley +1 more source
Learning from vertically distributed data across multiple sites: An efficient privacy-preserving algorithm for Cox proportional hazards model with variable selection. [PDF]
J Biomed InformMiao G +5 more
europepmc +1 more source
Advanced Science, EarlyView.Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra +9 more
wiley +1 more source
EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy
Advanced Science, EarlyView.This review provides new perspectives on EGFR's activation, mutations, and their impact on tumor immunotherapy. It summarizes how EGFR is activated and the current EGFR targeting strategy, evaluates their clinical outcomes in combination with immunotherapy, highlighting differential responses in tumors with EGFR wild‐type and different mutants.
Yuanzhuo Gu +7 more
wiley +1 more source
Advanced Science, EarlyView.This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo +17 more
wiley +1 more source
Single‐Droplet Dual‐Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening
Advanced Science, EarlyView.Circular RNAs are crucial in tumorigenesis. This study identifies circCK1γ3 and circWDR37 as dual plasma biomarkers for colorectal cancer (CRC) screening. It is developed Casµchip, a droplet microfluidic chip using Cas13a/b technology to quantify these biomarkers.
Jingsong Xu +11 more
wiley +1 more source
Tuning Parameter Selection in Cox Proportional Hazards Model with a Diverging Number of Parameters. [PDF]
Scand Stat Theory Appl, 2018 Ni A, Cai J.
europepmc +1 more source
Advanced Science, EarlyView.This study developed an unsupervised radiomics system integrating CT imaging and multi‐omics data to stratify clear cell renal cell carcinoma into two subtypes with distinct clinical outcomes. Cluster 1 showed lower recurrence risk and active immunity, while Cluster 2 exhibited higher recurrence risk, enriched VHL/KDM5C mutations, immunosuppressive ...
Yusheng Guo +14 more
wiley +1 more source
Identification of an eight-lncRNA prognostic model for breast cancer using WGCNA network analysis and a Cox‑proportional hazards model based on L1-penalized estimation. [PDF]
Int J Mol Med, 2019 Liu Z, Li M, Hua Q, Li Y, Wang G.
europepmc +1 more source
Advanced Science, EarlyView.Co‐administration with MHC class I‐ and II‐restricted neoantigens encoding mRNA‐based personalized cancer vaccines in a mouse CRC model can induce antigen‐specific immune responses and anti‐cancer effects. Notably, vaccination at an early stage of cancer development can have potent anti‐cancer effects. Furthermore, combining mRNA with immune checkpoint
Seongje Cho +26 more
wiley +1 more source