Results 71 to 80 of about 414,671 (320)

Weighted Cox Regression Using the R Package coxphw

Journal of Statistical Software, 2018
Cox's regression model for the analysis of survival data relies on the proportional hazards assumption. However, this assumption is often violated in practice and as a consequence the average relative risk may be under- or overestimated.
Daniela Dunkler, Meinhard Ploner, Michael Schemper, Georg Heinze   +3 more
doaj   +1 more source

Partially linear censored quantile regression [PDF]

, 2009
Censored regression quantile (CRQ) methods provide a powerful and flexible approach to the analysis of censored survival data when standard linear models are felt to be appropriate.
B Honore, JL Powell, K Doksum, L Peng, L Tian, M Buchinsky, R Koenker, R Koenker, R Koenker, RJ Gray, S Portnoy, Stephen Portnoy, T Neocleous, Tereza Neocleous, V Chernozhukov, X He, X He, X He   +17 more
core   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. [PDF]

, 2014
BackgroundThe age at onset of alcohol dependence (AD) is a critical moderator of genetic associations for alcohol dependence. The present study evaluated whether single nucleotide polymorphisms (SNPs) can influence the age at onset of AD in large high ...
Agrawal, Arpana, Almasy, Laura, Bertelsen, Sarah, Bierut, Laura, Bucholz, Kathleen, Budde, John, Dick, Danielle M, Edenberg, Howard J, Foroud, Tatiana, Goate, Alison, Harari, Oscar, Hesselbrock, Victor, Hinrichs, Anthony L, Kapoor, Manav, Kramer, John, Le, Nhung, Nurnberger, John I, Porjesz, Bernice, Rice, John, Schuckit, Marc, Tischfield, Jay, Wang, Jen-Chyong, Wetherill, Leah, Xiaoling, Xuei   +23 more
core   +1 more source

Using fractional polynomials and restricted cubic splines to model non‐proportional hazards or time‐varying covariate effects in the Cox regression model

Statistics in Medicine, 2021
The Cox proportional hazards model is used extensively in clinical and epidemiological research. A key assumption of this model is that of proportional hazards.
P. Austin, Jiming Fang, Douglas S. Lee
semanticscholar   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Testing Linear and Nonlinear Hypotheses in a Cox Proportional Hazards Model with Errors in Covariates

Lithuanian Journal of Statistics, 2019
We investigate linear and nonlinear hypotheses testing in a Cox proportional hazards model for right-censored survival data when the covariates are subject to measurement errors. In Kukush and Chernova (2018) [Theor. Probability and Math. Statist.
Oksana Chernova, Alexander Kukush
doaj   +1 more source

Implementation of complex interactions in a Cox regression framework [PDF]

, 2003
The standard Cox proportional hazards model has been extended by functionally describable interaction terms. The first of which are related to neural networks by adopting the idea of transforming sums of weighted covariables by means of a logistic ...
Müller, M., Ulm, Kurt
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source