Results 41 to 50 of about 882,801 (245)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

High-Dimensional Cox Regression Analysis in Genetic Studies with Censored Survival Outcomes

Journal of Probability and Statistics, 2012
With the advancement of high-throughput technologies, nowadays high-dimensional genomic and proteomic data are easy to obtain and have become ever increasingly important in unveiling the complex etiology of many diseases. While relating a large number of
Jinfeng Xu
doaj   +1 more source

Factors associated with extended remission in neovascular age-related macular degeneration on pro re nata treatment protocol. [PDF]

, 2020
AimTo show the characteristics and outcomes of patients with neovascular age-related macular degeneration (nAMD) who had extended remission (ER) while on a pro re nata (PRN) treatment protocol.MethodsThis was a retrospective case-control study of a ...
Amador-Patarroyo, Manuel J, Cheng, Lingyun, Dans, Kunny C, Freeman, William R, Lin, Tiezhu, Meshi, Amit, Muftuoglu, Ilkay Kilic   +6 more
core  

Building Cox-Type Structured Hazard Regression Models with Time-Varying Effects [PDF]

, 2008
In recent years, flexible hazard regression models based on penalised splines have been developed that allow us to extend the classical Cox-model via the inclusion of time-varying and nonparametric effects.
Hartl, Wolfgang, Hofner, Benjamin, Kneib, Thomas, Küchenhoff, Helmut   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Cox Regression in Survival Analysis: Practical Insights for Clinicians

Acta Médica Portuguesa
Survival analysis is a fundamental tool in clinical research for evaluating time-to-event outcomes. While the Kaplan-Meier method remains a widely used univariable approach for estimating survival probabilities and comparing groups, it does not account ...
António Gomes, Bruna Costa, Vitor Nunes, Constança Coelho   +3 more
doaj   +1 more source

Artificial Neural Network and Cox Regression Models for Predicting Mortality after Hip Fracture Surgery: A Population-Based Comparison

Medicina, 2020
This study purposed to validate the accuracy of an artificial neural network (ANN) model for predicting the mortality after hip fracture surgery during the study period, and to compare performance indices between the ANN model and a Cox regression model.
Cheng-Yen Chen, Yu-Fu Chen, Hong-Yaw Chen, Chen-Tsung Hung, Hon-Yi Shi   +4 more
doaj   +1 more source

Scalable Sparse Cox's Regression for Large-Scale Survival Data via Broken Adaptive Ridge

, 2018
This paper develops a new scalable sparse Cox regression tool for sparse high-dimensional massive sample size (sHDMSS) survival data. The method is a local $L_0$-penalized Cox regression via repeatedly performing reweighted $L_2$-penalized Cox regression.
Kawaguchi, Eric S., Li, Gang, Liu, Zhenqiu, Suchard, Marc A.   +3 more
core   +1 more source

Regression calibration for Cox regression under heteroscedastic measurement error - Determining risk factors of cardiovascular diseases from error-prone nutritional replication data [PDF]

, 2003
For instance nutritional data are often subject to severe measurement error, and an adequate adjustment of the estimators is indispensable to avoid deceptive conclusions.
Augustin, Thomas, Döring, A., Rummel, D.   +2 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source