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The role of CpG in DNA vaccines
Springer Seminars in Immunopathology, 2000One of the most exciting developments in the field of vaccine research in recent years has been DNA vaccines, with which immune responses are induced subsequent to the in vivo expression of antigen from directly introduced plasmid DNA. Strong immune responses have been demonstrated in a number of animal models against many viral, bacterial and ...
Michael J. McCluskie +2 more
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A review of CpGs and their relevance to aquaculture
Veterinary Immunology and Immunopathology, 2006CpG oligodeoxynucleotides (ODN) have been described as functioning as natural adjuvants because they promote professional antigen presenting cell (APC) function and co-stimulate lymphocytes. The majority of studies into the immune effects of CpG ODN to date have been carried out on mammals where they are proving very successful at stimulating innate ...
Christopher J. Secombes +1 more
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CpG Oligonucleotides as Vaccine Adjuvants
2020CpG Oligonucleotides (ODN) are immunomodulatory synthetic oligonucleotides specifically designed to stimulate Toll-like receptor 9. TLR9 is expressed on human plasmacytoid dendritic cells and B cells and triggers an innate immune response characterized by the production of Th1 and pro-inflammatory cytokines.
Neslihan Kayraklioglu +2 more
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Positives and negatives of methylated CpG [PDF]
Science, 2017 DNA Methylation When the DNA bases cytosine and guanine are next to each other, a methyl group is generally added to the pyrimidine, generating a mCpG dinucleotide. This modification alters DNA structure but can also affect function by inhibiting transcription factor (TF) binding. Yin et al.
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Australian & New Zealand Journal of Psychiatry, 2014
Philip Boyce, Philip Boyce
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Philip Boyce, Philip Boyce
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BioDrugs, 1998
The immune system appears to have evolved a mechanism to detect prokaryotic nucleic acids based on their content of unmethylated CpG dinucleotides in particular base contexts. This response promotes the activation of antigen-specific B cells and the secretion of T helper-1-like cytokines.
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The immune system appears to have evolved a mechanism to detect prokaryotic nucleic acids based on their content of unmethylated CpG dinucleotides in particular base contexts. This response promotes the activation of antigen-specific B cells and the secretion of T helper-1-like cytokines.
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CpG DNA in Cancer Immunotherapy
2000Anecdotal reports of tumor regression following systemic bacterial infection have been observed for centuries. The first reported attempt to explore this effect in a systematic fashion took place in the 1890s, when Dr. William Coley, a New York surgeon, performed a series of studies evaluating anti-tumor therapy with bacteria and bacterial products. Dr.
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Methylation Analysis of CpG Islands
2003The application of Southern blotting to determine the methylation status of a particular gene has already been alluded to in Chapter 17 by Tennant et al., and methodology for Southern blotting described. This chapter examines methylation analysis of CpG islands in more depth and describes a technique by which quantitative changes may be monitored with ...
Hermann Kneitz +2 more
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