CpG Site-Specific Regulation of Metallothionein-1 Gene Expression. [PDF]
Int J Mol Sci, 2020 Metal-binding inducible proteins called metallothioneins (MTs) protect cells from heavy-metal toxicity. Their transcription is regulated by metal response element (MRE)-binding transcription factor-1 (MTF1), which is strongly recruited to MREs in the MT ...
Ogushi S +3 more
europepmc +6 more sources
High density DNA methylation array with single CpG site resolution.
Genomics, 2011 We have developed a new generation of genome-wide DNA methylation BeadChip which allows high-throughput methylation profiling of the human genome. The new high density BeadChip can assay over 480K CpG sites and analyze twelve samples in parallel. The innovative content includes coverage of 99% of RefSeq genes with multiple probes per gene, 96% of CpG ...
M. Bibikova +11 more
semanticscholar +5 more sources
CpG Site-Based Signature Predicts Survival of Colorectal Cancer [PDF]
Biomedicines, 2022 Background: A critical unmet medical need in clinical management of colorectal cancer (CRC) pivots around lack of noninvasive and or minimally invasive techniques for early diagnosis and prognostic prediction of clinical outcomes. Because DNA methylation
Jiande Wu +4 more
doaj +4 more sources
Effects of non-CpG site methylation on DNA thermal stability: a fluorescence study. [PDF]
Nucleic Acids Res, 2015 Cytosine methylation is a widespread epigenetic regulation mechanism. In healthy mature cells, methylation occurs at CpG dinucleotides within promoters, where it primarily silences gene expression by modifying the binding affinity of transcription ...
Nardo L +7 more
europepmc +9 more sources
Mutation saturation for fitness effects at human CpG sites [PDF]
eLife, 2021 Whole exome sequences have now been collected for millions of humans, with the related goals of identifying pathogenic mutations in patients and establishing reference repositories of data from unaffected individuals.
Ipsita Agarwal, M. Przeworski
semanticscholar +6 more sources
CpG Sites Preferentially Methylated by Dnmt3a in Vivo [PDF]
Journal of Biological Chemistry, 2006 Dnmt3a and Dnmt3b are two major de novo DNA methyltransferases essential for embryonic development in mammals. It has been shown that Dnmt3a and Dnmt3b have distinct substrate preferences for certain genomic loci, including major and minor satellite repeats.
Masahiro Oka +4 more
openalex +5 more sources
Prognostic value of PLAGL1-specific CpG site methylation in soft-tissue sarcomas. [PDF]
PLoS ONE, 2013 Soft tissue sarcomas (STS) are rare, complex tumors with a poor prognosis. The identification of new prognostic biomarkers is needed to improve patient management.
Anne-Lise Peille +7 more
doaj +2 more sources
Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer [PDF]
Molecular and Cellular Biology, 1994 Cytosine methylation at CpG dinucleotides is thought to cause more than one-third of all transition mutations responsible for human genetic diseases and cancer.
A. N. Magewu, P. Jones
semanticscholar +2 more sources
CpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells. [PDF]
BMC Ophthalmol, 2016 BackgroundAge-related cataract (ARC) is the leading cause of visual impairment worldwide, and α-crystallin (CRYAA) is the predominant structural protein involved in the maintenance of lens clarity and refractive properties.
Liu X +6 more
europepmc +2 more sources
Decreased DNA methylation of a CpG site in the HBAP1 gene in plasma DNA from pregnant women. [PDF]
PLoS ONE, 2018 OBJECTIVE:The objective of this study is to identify potential CpG site(s) or DNA methylation pattern(s) in the pseudo α-globin 1 gene (HBAP1 gene), the gene which locates in α-thalassemia-1 deletion mutation, to differentiate plasma DNA between pregnant
Tanapat Pangeson +3 more
doaj +2 more sources