Results 111 to 120 of about 164,158 (344)

Determination of quantitative and site-specific DNA methylation of perforin by pyrosequencing

BMC Research Notes, 2009
Background Differential expression of perforin (PRF1), a gene with a pivotal role in immune surveillance, can be attributed to differential methylation of CpG sites in its promoter region.
Rajeevan Mangalathu S, Khin Maung M, Falkenberg Virginia R, Narasimhan Supraja   +3 more
doaj   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Methylation of the SPARC gene promoter and its clinical implication in pancreatic cancer

Journal of Experimental & Clinical Cancer Research, 2010
Background The secreted protein acidic and rich in cysteine (SPARC) plays a pivotal role in regulating cell-matrix interactions and tumor angiogenesis, proliferation, and migration.
Lv Shunli, Li Minghui, Cao Jia, Du Yiqi, Li Zhaoshen, Huang Haojie, Song Jian, Gao Jun, Lin Han, Gong Yanfang   +9 more
doaj   +1 more source

Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages. [PDF]

PLoS ONE, 2011
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG) stimulate innate immune responses. Phosphoinositide 3-kinase (PI3K) has been implicated in CpG-induced immune activation; however, its precise role has not yet been clarified.
Kaoru Hazeki, Yukiko Kametani, Hiroki Murakami, Masami Uehara, Yuki Ishikawa, Kiyomi Nigorikawa, Shunsuke Takasuga, Takehiko Sasaki, Tsukasa Seya, Misako Matsumoto, Osamu Hazeki   +10 more
doaj   +1 more source

DNA methylation and DNA methyltransferases [PDF]

, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H, Boulard, Mathieu, Edwards, John R, Yarychkivska, Olya   +3 more
core   +3 more sources

A Systematic Review of High Impact CpG Sites and Regions for MGMT Methylation in Glioblastoma [A Systematic Review of MGMT Methylation in GBM] [PDF]

, 2023
David R. Gibson, Hannah Lambing, Prithanjan Bhattacharya, Anh Huan Vo, Peggy Tahir, Farid Chehab, Nicholas Butowski   +6 more
openalex   +1 more source

DNA methylation in human epigenomes depends on local topology of CpG sites [PDF]

Nucleic Acids Research, 2016
In vertebrates, methylation of cytosine at CpG sequences is implicated in stable and heritable patterns of gene expression. The classical model for inheritance, in which individual CpG sites are independent, provides no explanation for the observed non-random patterns of methylation.
Lövkvist, C., Dodd, I., Sneppen, K., Haerter, J.   +3 more
openaire   +3 more sources

Unfolding and Degradation of Micellar Immunodrug Carriers Derived From End Group Modified Aliphatic Poly(Carbonate)s with Acid‐Responsive Ketal Side Groups

Advanced Materials, EarlyView.
An acid‐responsive polymeric micelle system based of aliphatic poly(carbonate)s with benzyl ketal side chains is designed for targeted immunodrug delivery. It can disassemble in endosomal environments, enabling site‐specific immunoactivation and enhanced biodegradability.
Adrian V. Hauck, Michael Fichter, Laura J. Rosenberger, Jannis Willig, Alexander Fuchs, Felicia Schön, Paul Schneider, Carolina Medina‐Montano, Taufiq Ahmad, Jessica Erlenbusch, Pol Besenius, Leonard Kaps, Matthias Bros, Stephan Grabbe, Volker Mailänder, Jürgen Groll, Lutz Nuhn   +16 more
wiley   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

DNA methylation differences within INS, PTPN22 and IL2RA promoters in lymphocyte subsets in children with type 1 diabetes and controls

Autoimmunity, 2023
We elucidated the effect of four known T1D-susceptibility associated single nucleotide polymorphism (SNP) markers in three genes (rs12722495 and rs2104286 in IL2RA, rs689 in INS and rs2476601 in PTPN22) on CpG site methylation of their proximal promoters
Sirpa Pahkuri, Ilse Ekman, Céline Vandamme, Kirsti Näntö-Salonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Tuure Kinnunen, Jorma Ilonen, Johanna Lempainen   +9 more
doaj   +1 more source