Results 131 to 140 of about 164,158 (344)

Protein engineering strategies for improving the selective methylation of target CpG sites by a dCas9-directed cytosine methyltransferase in bacteria.

PLoS ONE, 2018
Mammalian gene expression is a complex process regulated in part by CpG methylation. The ability to target methylation for de novo gene regulation could have therapeutic and research applications.
Tina Xiong, Dahlia Rohm, Rachael E Workman, Lauren Roundtree, Carl D Novina, Winston Timp, Marc Ostermeier   +6 more
doaj   +1 more source

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

Data from <i>TET2</i> Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor–Binding Sites in Chronic Myelomonocytic Leukemia

, 2023
Jumpei Yamazaki, Jaroslav Jelı́nek, Yue Lu, Matteo Cesaroni, Jozef Madžo, Frank Neumann, Rong He, Rodolphe F. Taby, Aparna Vasanthakumar, Trisha A. Macrae, Kelly R. Ostler, Hagop M. Kantarjian, Shoudan Liang, Marcos R. Estecio, Lucy A. Godley, Jean‐Pierre J. Issa   +15 more
openalex   +2 more sources

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus [PDF]

, 2010
BACKGROUND: Diabetic nephropathy is a serious complication of diabetes mellitus and is associated with considerable morbidity and high mortality.
A Buja, A Helgadottir, A Subramanian, AE Teschendorff, Alexander P Maxwell, Andrew E Teschendorff, AS O'Connor, B He, B Krause, BH Ramsahoye, C Weigert, Christopher G Bell, D Ansell, D Ingrosso, DA Tregouet, David A Savage, EJ Richards, ER Seaquist, F Eckhardt, G Lund, H Al-Kateb, H Makino, HN Ibrahim, JD Storey, JF Navarro-Gonzalez, JJ Rogus, JT Leek, K Ichinose, M Bibikova, M Bibikova, M Quinn, MG Pezzolesi, MG Pezzolesi, MM Suzuki, MP Turunen, NM Goldenberg, P Katavetin, R Ihaka, R Lister, R Sladek, RA Irizarry, RC Gentleman, S Beck, S Saxonov, Stephan Beck, T Hastie, TA Down, TJ Ekstrom, TS Leak, U.S Renal Data System, Vardhman K Rakyan   +50 more
core   +4 more sources

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Single quantum dot-based nanosensor for sensitive detection of 5-methylcytosine at both CpG and non-CpG sites

Chemical Science, 2018
We develop a single quantum dot (QD)-based nanosensor for sensitive detection of DNA methylation at both CpG and non-CpG sites.
Zi-yue Wang, Li-juan Wang, Qianyi Zhang, Bo Tang, Chun-yang Zhang   +4 more
openaire   +3 more sources

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA). [PDF]

, 2018
BackgroundEpigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health.ObjectiveWe sought to examine the associations of residential proximity to roadways at birth and ...
Agha, Golareh, Baccarelli, Andrea A, Cardenas, Andres, Coull, Brent A, de Kluizenaar, Yvonne, DeMeo, Dawn L, den Dekker, Martijn, Duijts, Liesbeth, Felix, Janine F, Gibson, Heike, Gilman, Matthew W, Gold, Diane R, Harris, Maria H, Hivert, Marie-France, Jaddoe, Vincent W, Litonjua, Augusto A, Oken, Emily, Peng, Cheng, Rifas-Shiman, Sheryl L, Sagiv, Sharon K, Schwartz, Joel   +20 more
core   +1 more source