Results 141 to 150 of about 164,158 (344)

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Enrichment analysis of Alu elements with different spatial chromatin proximity in the human genome [PDF]

, 2016
Transposable elements (TEs) have no longer been totally considered as “junk DNA” for quite a time since the continual discoveries of their multifunctional roles in eukaryote genomes.
A Antonaki, A Huda, A Nekrutenko, A Smallwood, AF Smit, AM Deaton, C Esnault, C Feschotte, CB Lowe, CT Ong, D Grover, D Grover, D Schmidt, D Xie, E Berezikov, E Lieberman-Aiden, E Wit de, E Yaffe, EP Nora, ES Lander, ES Lander, F Cui, G Bourque, G Kunarso, G Li, G Li, GA Maston, GJ Faulkner, GN Gallus, H Santos-Rosa, H Santos-Rosa, H Xie, HH Kazazian Jr, IK Jordan, J Banerji, J Dekker, J Dostie, J Jurka, J Jurka, J Ule, JA Yoder, JE Hambor, JF Brookfield, JF Brookfield, JM Chen, JR Dixon, JR Korenberg, K Ahn, K Kaer, KC Wang, L Lin, L Teng, M Hackenberg, M Simonis, M Weber, MA Batzer, MG Kidwell, MH Kagey, MJ Fullwood, MM Suzuki, ND Heintzman, NR Smalheiser, P Jin, P Medstrand, P Polak, R Cordaux, R Eskeland, R Lister, R Schneider, R Sorek, RD Hawkins, S Shen, S Winkler, SD Gillies, SL Oei, T Pastor, T Wicker, V Kapitonov, VJ Lynch, WD Gifford, Y Lu, Y Quentin, Y Quentin, Y Zhang   +83 more
core   +4 more sources

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand‐Symmetric and ‐Asymmetric 5‐Hydroxymethylcytosine‐Modifications in DNA

Advanced Science, EarlyView.
ABSTRACT The cytosine (C) modifications 5‐methylcytosine (mC) and 5‐hydroxymethylcytosine (hmC) are central regulatory elements of mammalian genomes. Both marks occur in double‐stranded DNA in either strand‐symmetric or ‐asymmetric fashion, but it is still poorly understood how this symmetry information is selectively read out by the nuclear proteome ...
Lena Engelhard, Zeyneb Vildan Cakil, Marlon S. Zambrano‐Mila, Simone Eppmann, Tye Gonzalez, Rasmus Linser, Petra Janning, Sidney Becker, Daniel Summerer   +8 more
wiley   +1 more source

Determination of methylated CpG sites in the promoter region of catechol-O-methyltransferase (COMT) and their involvement in the etiology of tobacco smoking

Frontiers in Psychiatry, 2010
We previously reported that catechol-O-methyltransferase (COMT) is significantly associated with nicotine dependence (ND) in humans. In this study, we examined whether there exists any difference in the extent of methylation of CpG dinucleotides in the ...
Qing Xu, Qing Xu, Jennie Z Ma, Thomas J Payne, Ming D Li   +4 more
doaj   +1 more source

SNP-by-CpG Site Interactions in ABCA7 Are Associated with Cognition in Older African Americans. [PDF]

Genes (Basel), 2022
Chaar DL, Nguyen K, Wang YZ, Ratliff SM, Mosley TH, Kardia SLR, Smith JA, Zhao W.   +7 more
europepmc   +1 more source

The Genome and Methylome of a Subsocial Small Carpenter Bee, Ceratina calcarata [PDF]

, 2016
Understanding the evolution of animal societies, considered to be a major transition in evolution, is a key topic in evolutionary biology. Recently, new gateways for understanding social evolution have opened up due to advances in genomics, allowing for ...
Glastad, Karl M., Hunt, Brendan G., Lawson, Sarah P., Rehan, Sandra M.   +3 more
core   +2 more sources

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Hypomethylation of a CpG Site in the CpG Island of the Aquaporin 1 Gene May Be Involved in the Formation of Adult-Onset Non-communicating Hydrocele Testis. [PDF]

Cureus, 2023
Hattori-Kato M, Okuno Y, Zaitsu M, Fukuhara H, Nomiya A, Mikami K, Takeuchi T.   +6 more
europepmc   +1 more source

From early stress to 12-month development in very preterm infants: Preliminary findings on epigenetic mechanisms and brain growth [PDF]

, 2018
Very preterm (VPT) infants admitted to Neonatal Intensive Care Unit (NICU) are at risk for altered brain growth and less-than-optimal socio-emotional development.
Borgatti, R., C., Squarcina, Carli, De, F., Brambilla, F., Sirgiovanni, Fumagalli, M., I., Giorda, L., Pozzoli, Montirosso, Rosario, Mosca, F., P., Dessimone, Provenzi, L., R., Cinnante, U., Triulzi   +13 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source