Results 151 to 160 of about 164,158 (344)

Maternal-infant interaction quality is associated with child NR3C1 CpG site methylation at 7 years of age. [PDF]

Am J Hum Biol, 2023
Holdsworth EA, Schell LM, Appleton AA.
europepmc   +1 more source

Time is encoded by methylation changes at clustered CpG sites

Cell Reports
AbstractAge-dependent changes in DNA methylation allow chronological and biological age inference, but the underlying mechanisms remain unclear. Using ultra-deep sequencing of >300 blood samples from healthy individuals, we show that age-dependent DNA methylation changes are regional and occur at multiple adjacent CpG sites, either stochastically or
Bracha-Lea Ochana, Daniel Nudelman, Daniel Cohen, Ayelet Peretz, Sheina Piyanzin, Ofer Gal, Amit Horn, Netanel Loyfer, Miri Varshavsky, Ron Raisch, Ilona Shapiro, Yechiel Friedlander, Hagit Hochner, Benjamin Glaser, Yuval Dor, Tommy Kaplan, Ruth Shemer   +16 more
openaire   +2 more sources

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

DNA methylation in the norepinephrine transporter gene promoter region is not associated with depression and hypertension

Clinical and Experimental Hypertension, 2017
Objective: This study aims to detect the role of DNA methylation in norepinephrine transporter (NET) gene promoter region on the association between depression and hypertension.
Lin Meng, Dongmei Chen, Fei Pei, Rutai Hui, Yang Zheng, Jingzhou Chen   +5 more
doaj   +1 more source

DNA methylation profiling of the human major histocompatibility complex: A pilot study for the Human Epigenome Project [PDF]

, 2004
The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA methylation phenomena. Occurring naturally on cytosine bases at cytosine-guanine dinucleotides, DNA methylation is intimately involved in diverse biological processes ...
Andrews, TD, Beck, S, Berlin, K, Cox, AV, Fischer, J, Gut, IG, Hildmann, T, Howe, KL, Lewin, J, Novik, KL, Olek, A, Otto, T, Rakyan, VK, Tost, J   +13 more
core  

A statistical method for excluding non-variable CpG sites in high-throughput DNA methylation profiling [PDF]

, 2010
Hailong Meng, Andrew R. Joyce, Daniel E. Adkins, P. Basu, Yankai Jia, Guoya Li, Tapas K. Sengupta, Barbara Zedler, E. Lenn Murrelle, Edwin J C G van den Oord   +9 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

DEAF1 binds unmethylated and variably spaced CpG dinucleotide motifs.

PLoS ONE, 2014
DEAF1 is a transcriptional regulator associated with autoimmune and neurological disorders and is known to bind TTCG motifs. To further ascertain preferred DEAF1 DNA ligands, we screened a random oligonucleotide library containing an "anchored" CpG motif.
Philip J Jensik, Jesse D Vargas, Sara N Reardon, Shivakumar Rajamanickam, Jodi I Huggenvik, Michael W Collard   +5 more
doaj   +1 more source

Association of IFN-γ +874 A/T SNP and hypermethylation of the -53 CpG site with tuberculosis susceptibility. [PDF]

Front Cell Infect Microbiol, 2023
Álvarez GI, Hernández Del Pino RE, Barbero AM, Estermann MA, Celano J, Musella RM, Palmero DJ, García VE, Pasquinelli V.   +8 more
europepmc   +1 more source

Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. [PDF]

, 2020
A significant number of X-linked genes escape from X chromosome inactivation and are associated with a distinct epigenetic signature. One epigenetic modification that strongly correlates with X-escape is reduced DNA methylation in promoter regions. Here,
Anderson, Johnathon D, Buchanan, Fiona KB, Cameron, David, Carter, Jasmine L, Coggins, Nicole B, Deng, Peter, Fink, Kyle D, Gonzalez, Casiana E, Halmai, Julian ANM, Halmai, Julian ANM, Lock, Samantha R, Nolta, Jan, O'Geen, Henriette, Segal, David J, Waldo, Jennifer J   +14 more
core   +1 more source