Results 161 to 170 of about 164,158 (344)

Constructing CPG Site-Specific Interstrand Locks for Single-Molecule Epigenetic Detection in a Nanopore [PDF]

, 2014
Insoon Kang, Yong Wang, Li‐Qun Gu, Corbin Reagan   +3 more
openalex   +1 more source

A CRISPR/Cas12a-assisted platform for identification and quantification of single CpG methylation sites [PDF]

, 2021
Jeanne E. van Dongen, Johanna Theodora Wilhelmina Berendsen, Jan C. T. Eijkel, Loes I. Segerink   +3 more
openalex   +1 more source

Correction: Single quantum dot-based nanosensor for sensitive detection of 5-methylcytosine at both CpG and non-CpG sites

Chemical Science, 2018
Correction for ‘Single quantum dot-based nanosensor for sensitive detection of 5-methylcytosine at both CpG and non-CpG sites’ by Zi-yue Wang et al., Chem. Sci., 2018, DOI: 10.1039/c7sc04813k.
Wang, Zi-yue, Wang, Li-juan, Zhang, Qianyi, Tang, Bo, Zhang, Chun-yang   +4 more
openaire   +3 more sources

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

DNA methyltransferase DNMT3A forms interaction networks with the CpG site and flanking sequence elements for efficient methylation. [PDF]

J Biol Chem, 2022
Dukatz M, Dittrich M, Stahl E, Adam S, de Mendoza A, Bashtrykov P, Jeltsch A.   +6 more
europepmc   +1 more source

A Prognostic Prediction Model Developed Based on Four CpG Sites and Weighted Correlation Network Analysis Identified DNAJB1 as a Novel Biomarker for Pancreatic Cancer [PDF]

, 2020
Lingming Kong, Peng Liu, Fei Xiang, Tianyu Wu, Zhongpeng Wang, Baohui Zhang, Jiatong Li, Xiaodong Tan   +7 more
openalex   +1 more source

Aberrant Methylation of Gene Associated CpG Sites Occurs in Borderline Personality Disorder

PLoS ONE, 2013
Borderline personality disorder (BPD) is a complex psychiatric disease with an increased impact in the last years. While the diagnosis and therapy are well established, little is known on the pathogenesis of borderline personality disorder. Previously, a significant increase in DNA methylation of relevant neuropsychiatric genes in BPD patients has been
Stefanie Teschler, Marek Bartkuhn, Natascha Künzel, Christian Schmidt, Steffen Kiehl, Gerhard Dammann, Reinhard Dammann   +6 more
openaire   +4 more sources

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

CpG site hypomethylation at ETS1‑binding region regulates DLK1 expression in Chinese patients with Tetralogy of Fallot. [PDF]

Mol Med Rep, 2022
Tian G, He L, Gu R, Sun J, Chen W, Qian Y, Ma X, Yan W, Zhao Z, Xu Z, Suo M, Sheng W, Huang G.   +12 more
europepmc   +1 more source

Identification of the origin of brain metastases based on the relative methylation orderings of CpG sites [PDF]

, 2020
Hui Liu, Jianming Chen, Haifeng Chen, Jie Xia, Ouxi Wang, Jiajing Xie, Meifeng Li, Zheng Guo, Guoping Chen, Haidan Yan   +9 more
openalex   +1 more source