CpG Site-Based Signature Predicts Survival of Colorectal Cancer [PDF]
Biomedicines, 2022 Background: A critical unmet medical need in clinical management of colorectal cancer (CRC) pivots around lack of noninvasive and or minimally invasive techniques for early diagnosis and prognostic prediction of clinical outcomes. Because DNA methylation
Jiande Wu +4 more
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CpG site methylation regulates mouse Rec8 gene promoter activity [PDF]
The Journal of Reproduction and DevelopmentThe Rec8 gene is specifically expressed in fetal and adult gonads. Although the importance of REC8 in gametogenesis is widely acknowledged, the mechanisms underlying its germ cell-specific expression remain unclear.
Mei RONG +3 more
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Decreased DNA methylation of a CpG site in the HBAP1 gene in plasma DNA from pregnant women. [PDF]
PLoS ONE, 2018 OBJECTIVE:The objective of this study is to identify potential CpG site(s) or DNA methylation pattern(s) in the pseudo α-globin 1 gene (HBAP1 gene), the gene which locates in α-thalassemia-1 deletion mutation, to differentiate plasma DNA between pregnant
Tanapat Pangeson +3 more
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Interleukin-4 Induces CpG Site-Specific Demethylation of the Pendrin Promoter in Primary Human Bronchial Epithelial Cells [PDF]
Cellular Physiology and Biochemistry, 2017 Pendrin is upregulated in bronchial epithelial cells following IL-4 stimulation via binding of STAT6 to an N4 GAS motif. Basal CpG methylation of the pendrin promoter is cell-specific.
Giada Scantamburlo +8 more
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A seven-m6A regulator-related CpG site-based prognostic signature for endometrial carcinoma. [PDF]
Medicine (Baltimore), 2021 Zhang X, Pang X, Huang Y, Qian S.
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CpG Site-Specific Regulation of Metallothionein-1 Gene Expression. [PDF]
Int J Mol Sci, 2020 Metal-binding inducible proteins called metallothioneins (MTs) protect cells from heavy-metal toxicity. Their transcription is regulated by metal response element (MRE)-binding transcription factor-1 (MTF1), which is strongly recruited to MREs in the MT promoters, in response to Zn and Cd. Mouse Mt1 gene promoter contains 5 MREs (a–e), and MTF1 has the
Ogushi S +3 more
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Mutation saturation for fitness effects at human CpG sites [PDF]
eLife, 2021 Whole exome sequences have now been collected for millions of humans, with the related goals of identifying pathogenic mutations in patients and establishing reference repositories of data from unaffected individuals. As a result, we are approaching an important limit, in which datasets are large enough that, in the absence of natural selection, every ...
Ipsita Agarwal, Molly Przeworski
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Hyperconserved CpG domains underlie Polycomb-binding sites [PDF]
Proceedings of the National Academy of Sciences, 2007 Comparative genomics of CpG dinucleotides, which are targets of DNA methyltransferases in vertebrate genomes, has been constrained by their evolutionary instability and by the effect of methylation on their mutation rates. We compared the human and chimpanzee genomes to identify DNA sequence signatures correlated with rates of mutation at CpG ...
Amos Tanay +3 more
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In silico identification of single nucleotide variations at CpG sites regulating CpG island existence and size [PDF]
Scientific Reports, 2022 AbstractGenetic and epigenetic modifications of genes involved in the key regulatory pathways play a significant role in the pathophysiology and progression of multifactorial diseases. The present study is an attempt to identify single nucleotide variations (SNVs) at CpG sites of promoters of ACAT1, APOB, APOE, CYBA, FAS, FLT1, KSR2, LDLR, MMP9, PCSK9,
Nivas Shyamala +6 more
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Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?
Epigenetics, 2022 Lifestyle-related phenotypes have been shown to be heritable and associated with DNA methylation. We aimed to investigate whether genetic predisposition to tobacco smoking, alcohol consumption, and higher body mass index (BMI) moderates the effect of ...
Chenglong Yu +13 more
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