Results 11 to 20 of about 4,459,503 (379)
High density DNA methylation array with single CpG site resolution
Genomics, 2011 We have developed a new generation of genome-wide DNA methylation BeadChip which allows high-throughput methylation profiling of the human genome. The new high density BeadChip can assay over 480K CpG sites and analyze twelve samples in parallel. The innovative content includes coverage of 99% of RefSeq genes with multiple probes per gene, 96% of CpG ...
Marina Bibikova +11 more
semanticscholar +5 more sources
Mutation saturation for fitness effects at human CpG sites [PDF]
eLife, 2021 Whole exome sequences have now been collected for millions of humans, with the related goals of identifying pathogenic mutations in patients and establishing reference repositories of data from unaffected individuals.
Ipsita Agarwal, M. Przeworski
semanticscholar +6 more sources
Cellular Physiology and Biochemistry, 2017 Pendrin is upregulated in bronchial epithelial cells following IL-4 stimulation via binding of STAT6 to an N4 GAS motif. Basal CpG methylation of the pendrin promoter is cell-specific.
Giada Scantamburlo +8 more
doaj +2 more sources
Correlation Between the Single-Site CpG Methylation and Expression Silencing of the XAF1 Gene in Human Gastric and Colon Cancers [PDF]
Gastroenterology, 2006 BACKGROUND & AIMS X-linked inhibitor of apoptosis protein (XIAP)-associated factor 1 (XAF1) antagonizes the anti-caspase activity of XIAP. XAF1 messenger RNA is present in normal tissues but undetectable in various cancers and thus poses a potential ...
Bing Zou +14 more
openalex +2 more sources
Modeling DNA methylation dynamics with approaches from phylogenetics [PDF]
Bioinformatics 30 (2014) i408-i414, 2014 Methylation of CpG dinucleotides is a prevalent epigenetic modification that is required for proper development in vertebrates, and changes in CpG methylation are essential to cellular differentiation. Genome-wide DNA methylation assays have become increasingly common, and recently distinct stages across differentiating cellular lineages have been ...
Capra, John A., Kostka, Dennis
arxiv +4 more sources
Clinical Epigenetics, 2016 Tobacco smoke is worldwide one of the main preventable lifestyle inhalative pollutants causing severe adverse health effects. Epidemiological studies revealed association of tobacco smoking with epigenetic changes at single CpGs in blood.
Mario Bauer +5 more
openalex +2 more sources
Epigenetic age-predictor for mice based on three CpG sites
eLife, 2018 Epigenetic clocks for mice were generated based on deep-sequencing analysis of the methylome. In this study we demonstrate that site-specific analysis of DNA methylation levels by pyrosequencing at only three CG dinucleotides (CpGs) in the genes Prima1 ...
Yang Han +6 more
semanticscholar +9 more sources
Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation
Biology Open, 2016 Advances in sequencing technology allow researchers to map genome-wide changes in DNA methylation in development and disease. However, there is a lack of experimental tools to site-specifically manipulate DNA methylation to discern the functional ...
James I. McDonald +9 more
doaj +2 more sources
CpG Sites Preferentially Methylated by Dnmt3a in Vivo [PDF]
Journal of Biological Chemistry, 2006 Dnmt3a and Dnmt3b are two major de novo DNA methyltransferases essential for embryonic development in mammals. It has been shown that Dnmt3a and Dnmt3b have distinct substrate preferences for certain genomic loci, including major and minor satellite repeats.
Masahiro Oka +4 more
openalex +5 more sources
Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer. [PDF]
Molecular and Cellular Biology, 1994 A. Nozibusiso Magewu, Peter A. Jones
openalex +2 more sources