Results 221 to 230 of about 164,158 (344)

Covalent Attachment of a Platinum(II) Complex inside DNA Duplexes

ChemistryEurope, EarlyView.
Oxidative addition is used for the site‐specific incorporation of an organometallic PtII complex as an artificial nucleobase into a DNA duplex. The platination stabilizes the duplex and confers it with phosphorescence. An organometallic phosphorescent PtII complex is introduced into DNA duplexes via oxidative addition to a tailor‐made artificial ...
Tim Schäfer, Iván Maisuls, Felix Boisten, Marian Hebenbrock, Alexander Hepp, Cristian A. Strassert, Jens Müller   +6 more
wiley   +1 more source

Predicting cervical cancer DNA methylation from genetic data using multivariate CMMP

Canadian Journal of Statistics, EarlyView.
Abstract Epigenetic modifications link the environment to gene expression and play a crucial role in tumour development. DNA methylation, in particular, is gaining attention in cancer research, including cervical cancer, the focus of this study.
Hang Zhang, Steven Chen, Raymond Balise, Jiming Jiang, Nagi Ayad, J. Sunil Rao   +5 more
wiley   +1 more source

Use of genome-wide DNA methylation analysis to identify prognostic CpG site markers associated with longer survival time in dogs with multicentric high-grade B-cell lymphoma. [PDF]

J Vet Intern Med
Teoh YB, Ishizaki T, Kagawa Y, Yokoyama S, Jelinek J, Matsumoto Y, Tomiyasu H, Tsujimoto H, Takiguchi M, Yamazaki J.   +9 more
europepmc   +1 more source

CpG island characterisation [PDF]

, 2005
Ongenaert, Maté, Van Criekinge, Wim
core   +1 more source

DMRdb: a disease-centric Mendelian randomization database for systematically assessing causal relationships of diseases with genes, proteins, CpG sites, metabolites and other diseases [PDF]

Xiao Zheng, Zhihao Tian, Xiaohui Che, Xu Zhang, Xiang Yu, Zhijian Ge, Zhaoyu Zhai, Qinfeng Ma, Jianbo Pan   +8 more
openalex   +1 more source

Mechanisms of Resistance to Cancer Immunotherapy: A Host–Tumor Interaction Perspective; A Review Article

Cancer Nexus, EarlyView.
Mechanisms of resistance to cancer immunotherapy from a host–tumor interaction perspective. The central tumor cell is protected by multiple resistance mechanisms, including genetic mutations, epigenetic modifications, and metabolic alterations. The immunosuppressive tumor microenvironment features myeloid‐derived suppressor cells (MDSCs), regulatory T ...
Mohammed Elmujtba Adam Essa, Hamid Noori, Abdelkareem A. Ahmed   +2 more
wiley   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

MicroRNA-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells by Targeting Methyl CpG-Binding Protein 2 [PDF]

, 2015
Guanmei Wen, Hanqing Zhao, Jianhua Zhu, Le Anh Luong, Li Zhang, Qingzhong Xiao, Qishan Chen, Shu Ye, Tayyab Adeel Afzal, Xiaotian Yu, Yu X, Yuan Huang   +11 more
core   +1 more source

Characterization of CpG sites that escape methylation on the inactive human X-chromosome

, 2015
Erika L. Moen, Edward Litwin, Stephen Arnovitz, Xu Zhang, Wei Zhang, M. Eileen Dolan, Lucy A. Godley   +6 more
openalex   +2 more sources

Rutaceae Zanthoxylum–Derived 7‐Demethylsuberosin Alleviates the Rheumatoid Arthritis Through Inhibiting the Maturation of Dendritic Cells via Targeting MAPK14 Functional Food‐Based 7‐Demethylsuberosin

Food Frontiers, EarlyView.
This study revealed that 7‐demethylsuberosin exhibits immunosuppressive effects both in vivo and in vitro. Furthermore, it inhibits the phosphorylation of MAPK14 by targeting it, thereby modulating dendritic cell (DC) maturation and function and reducing inflammation across various in vivo models.
Peng Han, Bo Wang, Luyang Han, Yanbo Zhu, Jiawei Dong, Yuekang Xu, Xiaoying Liu, Jinyao Li   +7 more
wiley   +1 more source