Results 281 to 290 of about 164,158 (344)

Genocopy of EVI1‐AML with paraneoplastic diabetes insipidus: PRDM16 overexpression by t(1;2)(p36;p21) and enhancer hijacking

British Journal of Haematology, EarlyView.
Summary Diabetes insipidus (DI) in patients with acute myeloid leukaemia (AML) and chromosome 3q alterations (EVI1/PRDM3/MECOM overexpression) constitutes a poorly understood paraneoplasia. A 44‐year‐old patient presented with clinical and morphological features of this syndrome but, surprisingly, disclosed the rare translocation t(1;2)(p36;p21), with ...
Julian List, Etienne Sollier, Fiona Brown‐Burke, Katherine Kelly, Dietmar Pfeifer, Valeria Shlyakhto, Kristina Maas‐Bauer, Milena Pantic, Christoph Plass, Michael Lübbert   +9 more
wiley   +1 more source

CoxMDS: multiple data splitting for high-dimensional mediation analysis with survival outcomes in epigenome-wide studies. [PDF]

Brief Bioinform
Yao M, Tian P, Li X, Bian S, Wang G, Gu Y, Navas-Acien A, Vardarajan BN, Belsky DW, Miller GW, Baccarelli AA, Liu Z.   +11 more
europepmc   +1 more source

Epigenetic silencing and pharmacological inhibition of EIF5A2 foster venetoclax sensitivity in acute myeloid leukaemia

British Journal of Haematology, EarlyView.
We show how the loss of activity of the translation initiation factor EIF5A2—either through gene hypermethylation or pharmacologic inhibition of its highly specific hypusine post‐translational modification—induces venetoclax sensitivity in acute myeloid leukaemia (AML) cells.
Eva Crespo‐García, Carlos Quero‐Dotor, Aleix Noguera‐Castells, Laia Sancho‐Vila, Laura Martinez‐Verbo, Manel Esteller   +5 more
wiley   +1 more source

End-repair causes methylation underestimation in cell-free DNA sequencing libraries. [PDF]

J Liq Biopsy
Groth TE, Mishin AA, Rao V, Tibet R, Troll CJ.   +4 more
europepmc   +1 more source

PCR-based methods to determine DNA methylation status at specific CpG sites using methylation-sensitive restriction enzymes [PDF]

, 2007
Helmtrud I. Roach, Ko Hashimoto
openalex  

The LaserSAFE technique for margin assessment during radical prostatectomy: a feasibility study

BJU International, EarlyView.
Objectives To assess the feasibility of conducting a multicentre trial comparing NeuroSAFE with a novel technique based on confocal laser microscopy (LaserSAFE) and evaluate the diagnostic performance of LaserSAFE for real‐time surgical margin assessment.
Ricardo Almeida‐Magana, Larissa Sena Teixeira Mendes, Eoin Dinneen, Tarek Al‐Hammouri, Aiman Haider, Anna Silvanto, Alex Freeman, Nicholas Roberts, Louise Dickinson, Chun Wah So, Zafer Tandogdu, Benjamin W. Lamb, Nikhil Mayor, Mathias Winkler, Hashim Ahmed, Greg Shaw   +15 more
wiley   +1 more source

Distinct DNA methylation in mother-infant dyads exposed to PM2.5 in pregnancy. [PDF]

Clin Epigenetics
Klibaner-Schiff E, Simonin EM, Kaushik A, Jung YS, Zhou X, Thompson E, Chinthrajah RS, Johnson MM, Nadeau KC.   +8 more
europepmc   +1 more source

Identification of a distinct epigenetic subgroup with inferior PFS in intracranial mesenchymal tumors with FET::CREB fusion

Brain Pathology, EarlyView.
Six new cases of intracranial mesenchymal tumors with FET::CREB fusion, alongside 20 previously reported cases underwent DNA methylation profiling uncovered a novel epigenetic subgroup distinguished by inferior PFS and unique clinicopathological, molecular, and epigenetic hallmarks.
Yong Lin, Yun Ning, Yang Lan, Yu‐Juan Cao, Rui‐Jiao Zhao, Hai‐Nan Li, Song Duan, Wei‐Wei Fu, Hai‐Bo Wu, Feng Wu, Xiu‐Wu Bian, Tao Luo, Xiao‐Hong Yao   +12 more
wiley   +1 more source

KoMethylNet: a novel epigenetic clock based on neural network analysis of DNA methylation data and epigenetic age acceleration in a Korean population. [PDF]

BMC Med
Yun D, Oh K, Kim Y, Ahn YM, Parikh HM, Meng X, Wang Z, Song N.   +7 more
europepmc   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source