Results 301 to 310 of about 164,158 (344)

From Genomic and Epigenomic Maps to Medicines in Adult T‐Cell Leukemia/Lymphoma

Cancer Science, EarlyView.
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive and refractory hematologic malignancy that is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. ATL results from a combination of viral latency and the accumulation of abnormalities throughout the genome, epigenome, transcriptome, and signaling pathways.
Kako Suzuki, Makoto Yamagishi
wiley   +1 more source

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, EarlyView.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source

DNA methylation predicts lung function and pulmonary exacerbation in sputum samples from patients with cystic fibrosis. [PDF]

Clin Epigenetics
Tost J, Caimmi D, Pastore M, Reynes C, Busato F, Pineau F, Claustres M, Vachier I, Chiron R, De Sario A.   +9 more
europepmc   +1 more source

Unraveling the Genetic Mysteries of Müllerian Anomalies: Research Approaches and Clinical Significance

Clinical Genetics, EarlyView.
This review primarily summarizes the genetic defects in Müllerian anomalies, the tools used to validate these genetic defects, and the future clinical significance of identifying the precise genetic etiology of Müllerian anomalies. ABSTRACT Müllerian anomalies are a collection of heterogeneous anatomical disorders of the female genital tract that ...
Jingfang Li, Xin Hou, Xiangyu Wang, Juan Li, Li Li, Xiangyi Ma   +5 more
wiley   +1 more source

DNA methylation and prediction of biological age. [PDF]

Front Mol Biosci
Chen Y, Cheng X, Ji S.
europepmc   +1 more source

Analysis of Human Uniparental Embryonic Stem Cells Reveals New Putative Imprinted Loci

Cell Proliferation, EarlyView.
To identify novel imprinted genes, parthenogenetic, androgenetic and biparental human embryonic stem cells and their differentiated neural progenitors were analysed by methylome and transcriptome profiling. This approach uncovered 12 putative novel imprinted genes, including a clustered region on chromosome 19, expanding the current catalogue of ...
Shay Kinreich, Nissim Benvenisty
wiley   +1 more source

Genome-wide methylation profiles of primary and matched distant metastasis: insights from the Dutch Early-Stage melanoma (D-ESMEL) study. [PDF]

Hum Genomics
Ouwerkerk J, Kerkour T, Mooyaart A, Zhou C, Boers R, Boers J, Gribnau J, Wakkee M, Li Y, Hollestein L.   +9 more
europepmc   +1 more source

Genetic risk factor identification for common epilepsies guided by integrative omics data analysis

Epilepsia, EarlyView.
Abstract Objective Genetic generalized epilepsies (GGEs) comprise the most common genetically determined epilepsy syndromes, following a complex mode of inheritance. Although many important common and rare genetic factors causing or contributing to these epilepsies have been identified in the past decades, many features of the genetic architecture are ...
Ashwini Mushunuri, Oluyomi Adesoji, Roland Krause, Patrick May, Holger Lerche, Albert Becker, Daniela Grimm, International League Against Epilepsy Consortium on Complex Epilepsies, Michael Nothnagel, Herbert Schulz   +9 more
wiley   +1 more source

Maternal DNA methylation signatures of gestational diabetes across all stages of pregnancy. [PDF]

J Transl Med
Srour L, Bejaoui Y, Jerobin J, Dweik M, Sankar A, Qannan A, Allouche Colak N, Chagoury O, Yousri NA, Farrell T, Fthenou E, Bashir M, El Hajj N.   +12 more
europepmc   +1 more source

Early-stage lung adenocarcinoma affects DNA methylation and gene expression in adjacent tissues. [PDF]

EMBO Rep
Wu Y, Wang Y, Tang Y, Xue J, Jiao Z, Li B, Wang S, Huang Z, Zheng X, Guan C, Wang D, Li J, Song L, Fung KL, Xu H, Li S, Zhu L, Chen JQ, Kerr DJ, Liang N, Wang Q, Chen Q.   +21 more
europepmc   +1 more source