Results 311 to 320 of about 164,158 (344)

Improved circulating tumor DNA profiling by simultaneous extraction of DNA methylation and copy number information from methylated DNA sequencing data. [PDF]

NPJ Precis Oncol
Hazelaar DM, Boers RG, Boers JB, de Weerd V, Helmijr J, Phm Jansen M, Mw Verheul H, Verhoef C, Gribnau J, Martens JW, Makrodimitris S, Wilting SM.   +11 more
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Identification and characterization of GHR gene promoter of yak. [PDF]

Sci Rep
Wu X, Chu M, Shi Y, Wang F, Ma X, Ge Q, Guo X, Liang C, Yan P.   +8 more
europepmc   +1 more source

Integrated genetic and epigenetic analysis identifies that rs939408 affects non-smoking lung adenocarcinoma risk by modulating the DNA methylation of LRRC2. [PDF]

Cell Death Dis
Zhang L, Li Z, Wang Y, Zhang M, Chen H, Cheng Y, Chen Q, Cui B, Liu J, Gong H, Zhu R, Tian T, Zhang Y, Ding S, Duan Y, Wu S, Chu M.   +16 more
europepmc   +1 more source

Hologenomic analysis of rectal mucus sampling for detection of adenomatous polyps and colorectal cancer. [PDF]

Nat Commun
Tock AJ, Patel KS, Morales-Walker E, Zhang L, Orthodoxou C, MacRitchie AD, Njoroge S, Olaniru OE, Mozolowski G, Mendes I, Baker DJ, Siew M, Humphrey HN, Walker-Davies ET, McDermott F, Spencer S, Bird S, Savva KV, Cunningham C, Rottenburg H, Sisodia H, Battersby NJ, Jones GAR, Lacy-Colson J, Baggaley AE, Peters CJ, Dodd A, Kang K, Hamon C, Crespillo-Casado A, Law E, Sands M, Lywood H, Page AJ, Daniels I, Wise D.   +35 more
europepmc   +1 more source

CpG Site-Specific Regulation of Metallothionein-1 Gene Expression

CpG Site-Specific Regulation of Metallothionein-1 Gene Expression
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TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites

Journal of Molecular Biology, 2021
In mammalian genomes, cytosine methylation occurs predominantly at CG (or CpG) dinucleotide contexts. As part of dynamic epigenetic regulation, 5-methylcytosine (mC) can be erased by active DNA demethylation, whereby ten-eleven translocation (TET) enzymes catalyze the stepwise oxidation of mC to 5-hydroxymethylcytosine (hmC), 5-formylcytosine (fC), and
Jamie E. DeNizio, Blaine J. Dow, Juan C. Serrano, Uday Ghanty, Alexander C. Drohat, Rahul M. Kohli   +5 more
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SVEP1 promoter regulation by methylation of CpG sites

Gene, 2011
SVEP1 gene encodes a cell adhesion molecule (CAM) that was previously shown to be expressed by cells related to skeletal tissues. Here we focus on SVEP1 expression regulation in pre-osteoblastic MBA-15 and mammary adenocarcinoma DA3 cells. We show that SVEP1 message and protein are highly expressed by MBA-15 when compared with DA3 cells.
C, Glait-Santar, D, Benayahu
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Demethylation of CpG sites in DNA of early rabbit trophoblast

Nature, 1981
The function of DNA methylation in eukaryotes is unknown. The introduction of methyl groups into the major groove of B-form DNA has been shown to affect DNA–protein interactions in prokaryotes1, and it is probable that they perform analogous functions in eukaryotic DNA. Thus, there is considerable interest in the possibility that DNA methylation may be
C, Manes, P, Menzel
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Base-Flipping Propensities of Unmethylated, Hemimethylated, and Fully Methylated CpG Sites

The Journal of Physical Chemistry B, 2013
Methylation of C5 of cytosines at CpG dinucleotide sites of the DNA is one of the most important factors regulating the expression of genes. The interactions of these CpG sites with proteins are essential for recognition and catalysis and in many cases are characterized by the flipping of either of the cytosine bases out of the DNA helix. In this paper,
Caterina Bianchi, Ronen Zangi
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Rare McArdle disease locus polymorphic site on 11q13 contains CpG sequence

Human Genetics, 1990
When probes throughout the McArdle disease (myophosphorylase) gene region were used to search for DNA polymorphisms, only an MspI polymorphism was found in 94 enzyme-probe combinations. Along with an insertion/deletion polymorphism more 3' to the gene locus, these polymorphisms will be informative in 75% of at-risk patients.
R V, Lebo, L A, Anderson, S, DiMauro, E, Lynch, P, Hwang, R, Fletterick   +5 more
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