Fetal DNA Methylation Associates with Early Spontaneous Preterm Birth and Gestational Age. [PDF]
PLoS ONE, 2013 Spontaneous preterm birth (PTB,
Sasha E Parets +7 more
doaj +1 more source
Methylated DNA recognition during the reversal of epigenetic silencing is regulated by cysteine and cerine residues in the Epstein-Barr Virus lytic switch protein [PDF]
, 2008 Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with various malignancies, including Burkitt's lymphoma and nasopharyngeal carcinoma.
A Prokhortchouk +31 more
core +3 more sources
CpG Deamination Creates Transcription Factor–Binding Sites with High Efficiency [PDF]
Genome Biology and Evolution, 2011 The formation of new transcription factor-binding sites (TFBSs) has a major impact on the evolution of gene regulatory networks. Clearly, single nucleotide mutations arising within genomic DNA can lead to the creation of TFBSs. Are molecular processes inducing single nucleotide mutations contributing equally to the creation of TFBSs?
Zemojtel, T. +5 more
openaire +3 more sources
Exploring genome wide bisulfite sequencing for DNA methylation analysis in livestock: a technical assessment [PDF]
, 2014 peer-reviewedRecent advances made in “omics” technologies are contributing to a revolution in livestock selection and breeding practices. Epigenetic mechanisms, including DNA methylation are important determinants for the control of gene expression in ...
Couldrey, Christine, Doherty, Rachael
core +2 more sources
BMC Genomics, 2006 Background Complementary single-nucleotide polymorphisms (SNPs) may not be distributed equally between two DNA strands if the strands are functionally distinct, such as in transcribed genes.
Majewski Jacek +4 more
doaj +1 more source
DNA Methylation-Mediated Downregulation of DEFB1 in Prostate Cancer Cells. [PDF]
PLoS ONE, 2016 Epigenetic aberrations play crucial roles in prostate cancer (PCa) development and progression. The DEFB1 gene, which encodes human ß-defensin-1 (HBD-1), contributes to innate immune responses and functions as a potential tumor suppressor in urological ...
Jaehyouk Lee +5 more
doaj +1 more source
Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients. [PDF]
, 2018 OBJECTIVE:Epigenetic modifications have previously been associated with rheumatoid arthritis (RA). In this study, we aimed to determine whether differential DNA methylation in peripheral blood cell subpopulations is associated with any of 4 clinical ...
Barcellos, Lisa F +13 more
core +1 more source
Nucleotide distance influences co-methylation between nearby CpG sites
Genomics, 2020 The tendency of individual CpG sites to be methylated is distinctive, non-random and well-regulated throughout the genome. We investigated the structural and spatial factors influencing CpGs methylation by performing an ultra-deep targeted methylation analysis on human, mouse and zebrafish genes.
Affinito +22 more
openaire +7 more sources
Amyloid Beta-Mediated Hypomethylation of Heme Oxygenase 1 Correlates with Cognitive Impairment in Alzheimer's Disease. [PDF]
PLoS ONE, 2016 To identify epigenetically regulated genes involved in the pathogenesis of Alzheimer's disease (AD) we analyzed global mRNA expression and methylation profiles in amyloid precursor protein (APP)-Swedish mutant-expressing AD model cells, H4-sw and ...
Hye Youn Sung +5 more
doaj +1 more source
The role of mutation rate variation and genetic diversity in the architecture of human disease [PDF]
, 2013 Background We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease.
A Hodgkinson +29 more
core +8 more sources