Results 41 to 50 of about 4,376,271 (343)

A novel family of beta mixture models for the differential analysis of DNA methylation data: an application to prostate cancer [PDF]

, 2022
Identifying differentially methylated cytosine-guanine dinucleotide (CpG) sites between benign and tumour samples can assist in understanding disease. However, differential analysis of bounded DNA methylation data often requires data transformation, reducing biological interpretability.
arxiv   +1 more source

Strand bias in complementary single-nucleotide polymorphisms of transcribed human sequences: evidence for functional effects of synonymous polymorphisms

BMC Genomics, 2006
Background Complementary single-nucleotide polymorphisms (SNPs) may not be distributed equally between two DNA strands if the strands are functionally distinct, such as in transcribed genes.
Majewski Jacek, Guo Fan, Lawrence Steve G, Qu Hui-Qi, Polychronakos Constantin   +4 more
doaj   +1 more source

Fetal DNA Methylation Associates with Early Spontaneous Preterm Birth and Gestational Age. [PDF]

PLoS ONE, 2013
Spontaneous preterm birth (PTB,
Sasha E Parets, Karen N Conneely, Varun Kilaru, Stephen J Fortunato, Tariq Ali Syed, George Saade, Alicia K Smith, Ramkumar Menon   +7 more
doaj   +1 more source

Amyloid Beta-Mediated Hypomethylation of Heme Oxygenase 1 Correlates with Cognitive Impairment in Alzheimer's Disease. [PDF]

PLoS ONE, 2016
To identify epigenetically regulated genes involved in the pathogenesis of Alzheimer's disease (AD) we analyzed global mRNA expression and methylation profiles in amyloid precursor protein (APP)-Swedish mutant-expressing AD model cells, H4-sw and ...
Hye Youn Sung, Byung-Ok Choi, Jee Hyang Jeong, Kyoung Ae Kong, Jinha Hwang, Jung-Hyuck Ahn   +5 more
doaj   +1 more source

Aberrant DNA methylation of the toll-like receptors 2 and 6 genes in patients with obstructive sleep apnea.

PLoS ONE, 2020
Obstructive sleep apnea (OSA) is a syndrome leading to chronic intermittent hypoxia, and the up-regulation of toll-like receptors (TLR) 2 and 6 on peripheral blood cells has been reported.
Kuo-Tung Huang, Yung-Che Chen, Chia-Cheng Tseng, Huang-Chih Chang, Mao-Chang Su, Ting-Ya Wang, Yong-Yong Lin, Yi-Xin Zheng, Jen-Chieh Chang, Chien-Hung Chin, Chang-Chun Hsiao, Meng-Chih Lin   +11 more
doaj   +1 more source

The prognostic significance of whole blood global and specific DNA methylation levels in gastric adenocarcinoma. [PDF]

PLoS ONE, 2010
BACKGROUND: Epigenetics, particularly DNA methylation, has recently been elucidated as important in gastric cancer (GC) initiation and progression.
Mansour S Al-Moundhri, Maryam Al-Nabhani, Letizia Tarantini, Andrea Baccarelli, Jennifer A Rusiecki   +4 more
doaj   +1 more source

Intergenic, gene terminal, and intragenic CpG islands in the human genome

BMC Genomics, 2010
Background Recently, it has been discovered that the human genome contains many transcription start sites for non-coding RNA. Regulatory regions related to transcription of this non-coding RNAs are poorly studied.
Kulakovskiy Ivan V, Ermakova Ekaterina O, Malko Dmitry B, Oparina Nina J, Fridman Marina V, Medvedeva Yulia A, Heinzel Andreas, Makeev Vsevolod J   +7 more
doaj   +1 more source

Modeling DNA methylation dynamics with approaches from phylogenetics [PDF]

Bioinformatics 30 (2014) i408-i414, 2014
Methylation of CpG dinucleotides is a prevalent epigenetic modification that is required for proper development in vertebrates, and changes in CpG methylation are essential to cellular differentiation. Genome-wide DNA methylation assays have become increasingly common, and recently distinct stages across differentiating cellular lineages have been ...
arxiv   +1 more source

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus

Human Molecular Genetics, 2014
Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown.
N. Acevedo, Lovisa E. Reinius, Dario Greco, Anna Gref, Christina Orsmark-Pietras, H. Persson, G. Pershagen, G. Hedlin, E. Mélen, A. Scheynius, J. Kere, C. Söderhäll   +11 more
semanticscholar   +1 more source

Effect of the assignment of ancestral CpG state on the estimation of nucleotide substitution rates in mammals

BMC Evolutionary Biology, 2008
Background Molecular evolutionary studies in mammals often estimate nucleotide substitution rates within and outside CpG dinucleotides separately. Frequently, in alignments of two sequences, the division of sites into CpG and non-CpG classes is based ...
Keightley Peter D, Gaffney Daniel J
doaj   +1 more source