Results 51 to 60 of about 164,158 (344)

Aberrant DNA methylation of the toll-like receptors 2 and 6 genes in patients with obstructive sleep apnea.

PLoS ONE, 2020
Obstructive sleep apnea (OSA) is a syndrome leading to chronic intermittent hypoxia, and the up-regulation of toll-like receptors (TLR) 2 and 6 on peripheral blood cells has been reported.
Kuo-Tung Huang, Yung-Che Chen, Chia-Cheng Tseng, Huang-Chih Chang, Mao-Chang Su, Ting-Ya Wang, Yong-Yong Lin, Yi-Xin Zheng, Jen-Chieh Chang, Chien-Hung Chin, Chang-Chun Hsiao, Meng-Chih Lin   +11 more
doaj   +1 more source

The prognostic significance of whole blood global and specific DNA methylation levels in gastric adenocarcinoma. [PDF]

PLoS ONE, 2010
BACKGROUND: Epigenetics, particularly DNA methylation, has recently been elucidated as important in gastric cancer (GC) initiation and progression.
Mansour S Al-Moundhri, Maryam Al-Nabhani, Letizia Tarantini, Andrea Baccarelli, Jennifer A Rusiecki   +4 more
doaj   +1 more source

The long-term impact of folic acid in pregnancy on offspring DNA methylation : follow-up of the Aberdeen folic acid supplementation trial (AFAST) [PDF]

, 2018
Funding This work was supported by the NIHR Bristol Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol.
Atkinson, Charlotte, Bhattacharya, Sohinee, Campbell, Doris, Gaunt, Tom, Hall, Marion, Herbert, Georgia, Kazmi, Nabila, McArdle, Wendy, Ness, Andy, Relton, Caroline L., Richmond, Rebecca C., Ring, Susan, Sharp, Gemma C., Smith, George Davey, Taylor, Caroline   +14 more
core   +3 more sources

Intergenic, gene terminal, and intragenic CpG islands in the human genome

BMC Genomics, 2010
Background Recently, it has been discovered that the human genome contains many transcription start sites for non-coding RNA. Regulatory regions related to transcription of this non-coding RNAs are poorly studied.
Kulakovskiy Ivan V, Ermakova Ekaterina O, Malko Dmitry B, Oparina Nina J, Fridman Marina V, Medvedeva Yulia A, Heinzel Andreas, Makeev Vsevolod J   +7 more
doaj   +1 more source

Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus [PDF]

, 1996
The methyl-CpG binding domain (MBD) proteins are key molecules in the interpretation of DNA methylation signals leading to gene silencing. We investigated their binding specificity at the constitutively methylated region of a CpG island containing the ...
Auriol, Emilie, Billard, Lise-Marie, Magdinier, Frédérique, Dante, Robert   +3 more
core   +2 more sources

Effect of the assignment of ancestral CpG state on the estimation of nucleotide substitution rates in mammals

BMC Evolutionary Biology, 2008
Background Molecular evolutionary studies in mammals often estimate nucleotide substitution rates within and outside CpG dinucleotides separately. Frequently, in alignments of two sequences, the division of sites into CpG and non-CpG classes is based ...
Keightley Peter D, Gaffney Daniel J
doaj   +1 more source

DNA methylation profiling identifies a high effect genetic variant for lipoprotein(a) levels

Epigenetics, 2020
Changes in whole blood DNA methylation levels at several CpG sites have been associated with circulating blood lipids, specifically high-density lipoprotein and triglycerides.
Gregory T. Jones, Judith Marsman, Basharat Bhat, Victoria L. Phillips, Aniruddha Chatterjee, Euan J. Rodger, Michael J. A. Williams, André M. van Rij, Sally P. A. McCormick   +8 more
doaj   +1 more source

VEZF1 elements mediate protection from DNA methylation [PDF]

, 2010
There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
AC Bell, Adam G. West, AG West, AG West, AG West, Alan Hair, CD Lewis, CL Li, D Macleod, F Antequera, F Recillas-Targa, Gary Felsenfeld, H Gowher, Humaira Gowher, IG Lin, J Aitsebaomo, J Stalder, JA Wallace, Jacqueline Dickson, JH Chung, JH Chung, JP Issa, KS Wendt, L Valenzuela, Lisa Stubbs, M Brandeis, M Gaszner, M Marin, M Oki, MC Barton, Miklos Gaszner, MJ Pikaart, MM Suzuki, MN Prioleau, MN Prioleau, MS Turker, N Koyano-Nakagawa, PA Jones, PB Talbert, PD Jackson, PE Szabo, R Buckle, R Jaenisch, R Kellum, R Straussman, Ruslan Strogantsev, S Fan, S Huang, S Huang, S Yao, SP Clark, T Hashimshony, V Mutskov, VJ Mutskov, VK Rakyan   +54 more
core   +5 more sources

Detection of suspicious interactions of spiking covariates in methylation data [PDF]

, 2020
BACKGROUND: In methylation analyses like epigenome-wide association studies, a high amount of biomarkers is tested for an association between the measured continuous outcome and different covariates.
Kruppa, Jochen, Richter, Gesa, Schaefer, Arne S., Sieg, Miriam   +3 more
core   +1 more source

Exaggerated CpH methylation in the autism-affected brain. [PDF]

, 2017
BackgroundThe etiology of autism, a complex, heritable, neurodevelopmental disorder, remains largely unexplained. Given the unexplained risk and recent evidence supporting a role for epigenetic mechanisms in the development of autism, we explored the ...
Arking, Dan E, Ellis, Shannon E, Gupta, Simone, Moes, Anna, West, Andrew B   +4 more
core   +1 more source