Results 61 to 70 of about 164,158 (344)

Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes. [PDF]

, 2017
ObjectiveTo determine whether differentially methylated CpGs in synovium-derived fibroblast-like synoviocytes (FLS) of patients with rheumatoid arthritis (RA) were also differentially methylated in RA peripheral blood (PB) samples.MethodsFor this study ...
Barcellos, Lisa F, Cole, Michael, Criswell, Lindsey A, Firestein, Gary S, Graf, John, Halperin, Eran, Harrison, Ruby, Holingue, Calliope, Link, Thomas, Quach, Diana, Quach, Hong L, Rahmani, Elior, Rhead, Brooke, Shah, Khooshbu, Shao, Xiaorong, Sinclair, Elizabeth, Wang, Wei   +16 more
core   +1 more source

Sensitive and quantitative universal Pyrosequencing™ methylation analysis of CpG sites [PDF]

BioTechniques, 2003
DNA methylation is implicated inmultiple normal cellular processes, in-cluding the regulation of tissue- and de-velopment-specific gene expression,imprinting, X-chromosome inactiva-tion, DNA repair, and the suppressionof parasitic DNA sequences. Aberrantgene promoter methylation and result-ing altered gene expression have beenassociated with cancers (1,
Colella, Stefano, Shen, L, Baggerly, K A, Issa, J P, Krahe, R   +4 more
openaire   +5 more sources

Methylation levels of SLC23A2 and NCOR2 genes correlate with spinal muscular atrophy severity.

PLoS ONE, 2015
Spinal muscular atrophy (SMA) is a monogenic neurodegenerative disorder subdivided into four different types. Whole genome methylation analysis revealed 40 CpG sites associated with genes that are significantly differentially methylated between SMA ...
Galina Yu Zheleznyakova, Emil K Nilsson, Anton V Kiselev, Marianna A Maretina, Lyudmila I Tishchenko, Robert Fredriksson, Vladislav S Baranov, Helgi B Schiöth   +7 more
doaj   +1 more source

The number of methylated CpG sites within the MGMT promoter region linearly correlates with outcome in glioblastoma receiving alkylating agents

Acta Neuropathologica Communications, 2021
MGMT-promoter methylation is associated with favorable outcome in glioblastoma. The aim of this study was to determine whether the absolute number of methylated Cytosine-Guanine-dinucleotide-(CpG-)sites within the DMR-2 island of the MGMT-promoter may ...
Sebastian Siller, Michael Lauseker, Philipp Karschnia, Maximilian Niyazi, Sabina Eigenbrod, Armin Giese, Joerg-Christian Tonn   +6 more
doaj   +1 more source

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]

, 2018
Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D, Chavez, Michael, Davis, Ryan R, Ferrara, Katherine W, Fite, Brett Z, Hubbard, Neil E, Ilovitsh, Asaf, Ingham, Elizabeth S, Mahakian, Lisa M, Monjazeb, Arta M, Murphy, William J, Silvestrini, Matthew T, Tam, Sarah M, Tepper, Clifford G   +13 more
core   +1 more source

Substitution rate variation at human CpG sites correlates with non-CpG divergence, methylation level and GC content [PDF]

Genome Biology, 2011
Abstract Background A major goal in the study of molecular evolution is to unravel the mechanisms that induce variation in the germ line mutation rate and in the genome-wide mutation profile. The rate of germ line mutation is considerably higher for cytosines at CpG sites than for any other nucleotide in ...
Mugal, Carina, Ellegren, Hans
openaire   +3 more sources

Identification of Prognostic Immune-Related Genes by Integrating mRNA Expression and Methylation in Lung Adenocarcinoma

International Journal of Genomics, 2020
Background. There is plenty of evidence showing that immune-related genes (IRGs) and epigenetic modifications play important roles in the biological process of cancer.
Jie Zhu, Min Wang, Daixing Hu
doaj   +1 more source

DNA Methylation Inhibits the Expression of CFSH in Mud Crab

Frontiers in Endocrinology, 2020
Crustacean female sex hormone (CFSH) is a key regulator of crustacean sex differentiation. The expression of Sp-CFSH in the mud crab Scylla paramamosain showed a tissue-specific and gender-variant pattern.
Qingling Jiang, Dongdong Lin, Huiyang Huang, Guizhong Wang, Haihui Ye   +4 more
doaj   +1 more source

Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting [PDF]

, 2015
Among mammals, only eutherians and marsupials are viviparous and have genomic imprinting that leads to parent-of-origin-specific differential gene expression. We used comparative analysis to investigate the origin of genomic imprinting in mammals. PEG10 (
Alsop, Amber, Graves, Jennifer, Ishino, Fumitoshi, Kaneko-Ishino, Tomoko, Kohara, Yuji, Kohda, Takashi, Narita, Takanori, Ono, Ryuichi, Pask, Andrew J, Renfree, Marilyn B, Shaw, Geoffrey, Suzuki, Shunsuke, Wang, Changshan   +12 more
core   +1 more source

A Subset of Methylated CpG Sites Differentiate Psoriatic from Normal Skin [PDF]

Journal of Investigative Dermatology, 2012
Psoriasis is a chronic inflammatory immune-mediated disorder affecting the skin and other organs including joints. Over 1,300 transcripts are altered in psoriatic involved skin compared with normal skin. However, to our knowledge, global epigenetic profiling of psoriatic skin is previously unreported.
Roberson, Elisha DO, Liu, Ying, Ryan, Caitriona, Joyce, Cailin E, Duan, Shenghui, Cao, Li, Martin, Ann, Liao, Wilson, Menter, Alan, Bowcock, Anne M   +9 more
openaire   +4 more sources