Results 61 to 70 of about 4,376,271 (343)

CpG Site–Specific Hypermethylation of p16INK4α in Peripheral Blood Lymphocytes of PAH-Exposed Workers

Cancer Epidemiology, Biomarkers and Prevention, 2011
Background: Sufficient epidemiologic evidence shows an etiologic link between polycyclic aromatic hydrocarbons (PAH) exposure and lung cancer risk. While the genetic modifications have been found in PAH-exposed population, it is unclear whether gene ...
Ping Yang, Junxiang Ma, Bo Zhang, H. Duan, Zhini He, Jun-ling Zeng, Xiao-wen Zeng, Daochuan Li, Qing Wang, Yong-mei Xiao, Caixia Liu, Qin Xiao, Li-ping Chen, Xiaonian Zhu, X. Xing, Zhifang Li, Shixin Zhang, Zhengbao Zhang, Lu Ma, E. Wang, Z. Zhuang, Yu-xin Zheng, Wen Chen   +22 more
semanticscholar   +1 more source

A Subset of Methylated CpG Sites Differentiate Psoriatic from Normal Skin [PDF]

Journal of Investigative Dermatology, 2012
Psoriasis is a chronic inflammatory immune-mediated disorder affecting the skin and other organs including joints. Over 1,300 transcripts are altered in psoriatic involved skin compared with normal skin. However, to our knowledge, global epigenetic profiling of psoriatic skin is previously unreported.
Roberson, Elisha DO, Liu, Ying, Ryan, Caitriona, Joyce, Cailin E, Duan, Shenghui, Cao, Li, Martin, Ann, Liao, Wilson, Menter, Alan, Bowcock, Anne M   +9 more
openaire   +4 more sources

Identification of Prognostic Immune-Related Genes by Integrating mRNA Expression and Methylation in Lung Adenocarcinoma

International Journal of Genomics, 2020
Background. There is plenty of evidence showing that immune-related genes (IRGs) and epigenetic modifications play important roles in the biological process of cancer.
Jie Zhu, Min Wang, Daixing Hu
doaj   +1 more source

DNA Methylation Inhibits the Expression of CFSH in Mud Crab

Frontiers in Endocrinology, 2020
Crustacean female sex hormone (CFSH) is a key regulator of crustacean sex differentiation. The expression of Sp-CFSH in the mud crab Scylla paramamosain showed a tissue-specific and gender-variant pattern.
Qingling Jiang, Dongdong Lin, Huiyang Huang, Guizhong Wang, Haihui Ye   +4 more
doaj   +1 more source

HPA axis dysregulation is associated with differential methylation of CpG-sites in related genes [PDF]

Scientific Reports, 2021
AbstractDNA methylation shifts in Hypothalamic–pituitary–adrenal (HPA) axis related genes is reported in psychiatric disorders including hypersexual disorder. This study, comprising 20 dexamethasone suppression test (DST) non-suppressors and 73 controls, examined the association between the HPA axis dysregulation, shifts in DNA methylation of HPA axis ...
Helgi B. Schiöth, Helgi B. Schiöth, Andreas Chatzittofis, Andreas Chatzittofis, Adrian Desai E. Boström, Adrian Desai E. Boström, Katarina Öberg, Jussi Jokinen, Jussi Jokinen, Stefan Arver, Diana M. Ciuculete   +10 more
openaire   +5 more sources

Advances in the pathogenesis of Rett syndrome using cell models

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 532-541, December 2022., 2022
Most Rett syndrome (RTT) patients are affected by the MECP2 gene mutations. And the mutations of MECP2 have wide effects on different cell types of nervous system, including neurons, astrocytes, oligodendrocytes and microglia, which always combined together to lead to abnormalities in the whole neural network.
Sijia Lu, Yongchang Chen, Zhengbo Wang
wiley   +1 more source

Volumetric Analysis of Glioblastoma for Determining Which CpG Sites Should Be Tested by Pyrosequencing to Predict Temozolomide Efficacy

Biomolecules, 2022
The aim of the present study was to determine which individual or combined CpG sites among O6-methylguanine DNA methyltransferase CpG 74–89 in glioblastoma mainly affects the response to temozolomide resulting from CpG methylation using statistical ...
Tomohiro Hosoya, Masamichi Takahashi, Calvin Davey, Jun Sese, Mai Honda-Kitahara, Yasuji Miyakita, Makoto Ohno, Shunsuke Yanagisawa, Takaki Omura, Daisuke Kawauchi, Yukie Ozeki, Miyu Kikuchi, Tomoyuki Nakano, Akihiko Yoshida, Hiroshi Igaki, Yuko Matsushita, Koichi Ichimura, Yoshitaka Narita   +17 more
doaj   +1 more source

DMseg: a Python algorithm for de novo detection of differentially or variably methylated regions [PDF]

arXiv, 2023
Detecting and assessing statistical significance of differentially methylated regions (DMRs) is a fundamental task in methylome association studies. While the average differential methylation in different phenotype groups has been the inferential focus, methylation changes in chromosomal regions may also present as differential variability, i.e ...
arxiv  

CpG site-specific RASSF1a hypermethylation is associated with occupational PAH exposure and genomic instability

, 2015
Previous studies have shown an etiologic link between exposure to polycyclic aromatic hydrocarbons (PAHs) and lung cancer development. While the tumor suppressor gene RASSF1a is mostly silenced by DNA methylation in various tumors, it is unclear whether ...
Zhini He, H. Duan, Biao Zhang, Miao Li, Liping Chen, Bo Zhang, Xiaonian Zhu, Chen Gao, Jie Li, Xiao Zhang, Jingmaio Zhang, Shan Wang, Xiao-wen Zeng, Daochuan Li, X. Xing, Zhengbao Zhang, Lu Ma, Qing Bai, Caixia Liu, Yong-mei Xiao, Yu-xin Zheng, Wen Chen   +21 more
semanticscholar   +1 more source

Predicting genome-wide DNA methylation using methylation marks, genomic position, and DNA regulatory elements [PDF]

, 2013
Background: Recent assays for individual-specific genome-wide DNA methylation profiles have enabled epigenome-wide association studies to identify specific CpG sites associated with a phenotype. Computational prediction of CpG site-specific methylation levels is important, but current approaches tackle average methylation within a genomic locus and are
arxiv   +1 more source