Results 71 to 80 of about 164,158 (344)

Genome-wide identification of methylated CpG sites in nongenital cutaneous warts [PDF]

BMC Medical Genomics, 2020
AbstractBackgroundLow-risk HPV infection has not been the subject of epigenetic investigation. The present study was carried out in order to investigate the methylation status of CpG sites in non-genital cutaneous warts.MethodsGenomic DNA was extracted from 24 paired epidermal samples of warts and normal skin.
Laith N. AL-Eitan, Mansour A. Alghamdi, Amneh H. Tarkhan, Firas A. Al-Qarqaz   +3 more
openaire   +3 more sources

Volumetric Analysis of Glioblastoma for Determining Which CpG Sites Should Be Tested by Pyrosequencing to Predict Temozolomide Efficacy

Biomolecules, 2022
The aim of the present study was to determine which individual or combined CpG sites among O6-methylguanine DNA methyltransferase CpG 74–89 in glioblastoma mainly affects the response to temozolomide resulting from CpG methylation using statistical ...
Tomohiro Hosoya, Masamichi Takahashi, Calvin Davey, Jun Sese, Mai Honda-Kitahara, Yasuji Miyakita, Makoto Ohno, Shunsuke Yanagisawa, Takaki Omura, Daisuke Kawauchi, Yukie Ozeki, Miyu Kikuchi, Tomoyuki Nakano, Akihiko Yoshida, Hiroshi Igaki, Yuko Matsushita, Koichi Ichimura, Yoshitaka Narita   +17 more
doaj   +1 more source

Methyl CpG binding protein 2 (MeCP2) enhances photodimer formation at methyl-CpG sites but suppresses dimer deamination [PDF]

Nucleic Acids Research, 2010
Spontaneous deamination of cytosine to uracil in DNA is a ubiquitous source of C→T mutations, but occurs with a half life of ∼50 000 years. In contrast, cytosine within sunlight induced cyclobutane dipyrimidine dimers (CPD's), deaminate within hours to days.
Cannistraro, Vincent J., Taylor, John-Stephen A.   +1 more
openaire   +2 more sources

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. [PDF]

, 2010
Analysis of DNA methylation patterns relies increasingly on sequencing-based profiling methods. The four most frequently used sequencing-based technologies are the bisulfite-based methods MethylC-seq and reduced representation bisulfite sequencing (RRBS),
A Bird, A Hellman, A Meissner, AD Smith, Adam Olshen, AK Maunakea, Aleksandar Milosavljevic, Alexander Meissner, Allen Delaney, Andreas Gnirke, AP Feinberg, B Langmead, Bing Ren, Bradley E Bernstein, Brett E Johnson, C Coarfa, C Grunau, Charles B Epstein, Chibo Hong, Christoph Bock, Cristian Coarfa, D Serre, David Haussler, DM Duhl, FV Jacinto, G Bourque, G Kunarso, G Robertson, H Gu, H Lin, H O'Geen, Henriette O'Geen, Hongcang Gu, J Deng, Joseph F Costello, Joseph R Ecker, Junchen Gu, KD Robertson, Kevin J Forsberg, KR Blahnik, KS Pollard, LC Schalkwyk, Lorigail Echipare, M Pick, M Tahiliani, MA Gama-Sosa, Marco A Marra, Martin Hirst, Mattia Pelizzola, Michael Q Zhang, MP Ball, P Arnaud, Peggy J Farnham, PVK Pant, R Alan Harris, R David Hawkins, R Lister, R Lister, RA Waterland, RA Waterland, Raman P Nagarajan, Robert A Waterland, Ryan Lister, S Ito, S Kriaucionis, Sara L Downey, Shaun D Fouse, SJ Cokus, T Wang, TA Down, TE Ludwig, Ting Wang, Tracy Ballinger, Wei Li, Wen-Yu Chung, Xin Zhou, Y Xi, Yongjun Zhao, Yuanxin Xi, ZD Smith   +79 more
core   +2 more sources

DNA methylation at individual CpG-sites of EPB41L3, HTERT and FAM19A4 are useful for detection of cervical high-grade squamous intraepithelial lesions (HSIL) or worse: Analysis of individual CpG-sites outperforms averaging

Tumour Virus Research
Global methylation analysis of gene promoters is promising for detection of high-grade squamous intraepithelial lesions or worse (HSIL+) in high-risk human papillomavirus (hrHPV)-positive women.
Monica Molano, Dorothy A. Machalek, Samuel Phillips, Grace Tan, Suzanne M. Garland, David Hawkes, Prisha Balgovind, Reza Haqshenas, Steve G. Badman, John Bolnga, Josephine Gabuzzi, Zure Kombati, Gloria M. Munnull, Julia ML. Brotherton, Marion Saville, John M. Kaldor, Pamela J. Toliman, Andrew J. Vallely, Gerald L. Murray   +18 more
doaj   +1 more source

Directed evolution of improved zinc finger methyltransferases. [PDF]

PLoS ONE, 2014
The ability to target DNA methylation toward a single, user-designated CpG site in vivo may have wide applicability for basic biological and biomedical research.
Brian Chaikind, Marc Ostermeier
doaj   +1 more source

T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment

Journal for ImmunoTherapy of Cancer, 2021
Background We previously reported CpG-B injection at the primary tumor excision site prior to re-excision and sentinel node biopsy to result in immune activation of the sentinel lymph node (SLN), increased melanoma-specific CD8+ T cell rates in ...
Tanja D de Gruijl, M Petrousjka van den Tol, Bas D Koster, Rik J Scheper, Barbara G Molenkamp, Alfons JM van den Eertwegh, Mari FCM van den Hout, Berbel JR Sluijter, Paul AM van Leeuwen, Marta López González, Annelies W Turksma, Saskia Vosslamber, Ekaterina J Jordanova   +12 more
doaj   +1 more source

Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva [PDF]

, 2018
BackgroundCorticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses overexposed to cortisol have increased risks of disease in later life.
A Cardenas, A Crudo, A Gavrila, Andrea A. Baccarelli, Andres Cardenas, Augusto A. Litonjua, C Lesseur, C Newton-Cheh, CA Sandman, CA Sandman, CE Boeke, CS Mantzoros, CV Breton, DA Kertes, Dawn L. DeMeo, DM O’Connor, E Baibazarova, E Marinoni, E Oken, E Oken, E Salvi, Emily Oken, ER Gibney, FI Milagro, Fu-Ying Tian, H Masuzaki, I Melzner, IC McMillen, Janet W. Rich-Edwards, JD Swinny, JJ Bonfiglio, JM Sheen, JT Smith, JW Rich-Edwards, K Barber, K Boekelheide, L Bouchard, LE Reinius, M Graff, M Urbanek, Mao-Meng Tiao, Marie-France Hivert, Matthew W. Gillman, MC García-Cardona, MC Sugden, MH Fasting, MW Gillman, MW Logue, N Alexander, N Sonenberg, ND Saenen, NJ Westphal, PD Wadhwa, PJ Trainer, R Kadakia, RL Emanuel, RS Ahima, RX Ren, S Pauwels, S Ramchandani, SA Obermann-Borst, Sheryl L. Rifas-Shiman, SJ McClennen, SJ McClennen, SY Moon, TA Dardeno, TC Martin, TJ Peters, VG Moisiadis, Y Chen, YC Chen, YD Salinas, Zari Dastani   +72 more
core   +1 more source

Epigenetic age-predictor for mice based on three CpG sites

eLife, 2018
Epigenetic clocks for mice were generated based on deep-sequencing analysis of the methylome. Here, we demonstrate that site-specific analysis of DNA methylation levels by pyrosequencing at only three CG dinucleotides (CpGs) in the genes Prima1 , Hsf4 ,
Yang Han, Monika Eipel, Julia Franzen, Vadim Sakk, Bertien Dethmers-Ausema, Laura Yndriago, Ander Izeta, Gerald de Haan, Hartmut Geiger, Wolfgang Wagner   +9 more
openaire   +6 more sources

Methylation levels of the TNFA gene are different between Graves’ and Hashimoto’s diseases and influenced by the TNFA polymorphism

Autoimmunity, 2018
Graves’ disease (GD) and Hashimoto’s disease (HD) are different pathological types of autoimmune thyroid diseases (AITDs). However, the epigenetic differences between these diseases have not been elucidated.
Emi Morita, Mikio Watanabe, Naoya Inoue, Hidemi Hashimoto, Emi Haga, Yoh Hidaka, Yoshinori Iwatani   +6 more
doaj   +1 more source