Results 41 to 50 of about 263,382 (282)

Neutrino and doubly charged Higgs boson phenomenology in flavored-TNMSSM

Nuclear Physics B, 2022
We develop a neutrino mass model based on A4×Z3 flavor symmetry in the context of the NMSSM extended by supersymmetric type II seesaw mechanism (flavored-TNMSSM).
M.A. Ouahid, R. Ahl Laamara
doaj   +1 more source

Evaluation of Constant Potential Method in Simulating Electric Double-Layer Capacitors [PDF]

, 2014
A major challenge in the molecular simulation of electric double layer capacitors (EDLCs) is the choice of an appropriate model for the electrode. Typically, in such simulations the electrode surface is modeled using a uniform fixed charge on each of the
Asta, Mark, Laird, Brian B., Olmsted, David L., Wang, Zhenxing, Yang, Yang   +4 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Lattice Chern-Simons model for FQHE

Nuclear Physics B, 2023
Motivated by [60][61] and using topological invariance and cycle homology, we construct an effective gauge invariant lattice Chern-Simons (CS) model for the fractional quantum Hall effect (FQHE) with applications to (i) the Laughlin state on 3D crystals,
S. Boukaddid, R. Ahl Laamara, L.B. Drissi, E.H. Saidi, J. Zerouaoui   +4 more
doaj   +1 more source

If CPM is so bad, why have we been using it so long? [PDF]

, 2014
Why has the Critical Path Method (CPM) been used so widely for so long given its inability to produce predictable outcomes? For shedding light on this paradox, the formative period of the CPM is analysed from two main angles.
Dave, Bhargav, Howell, Greg, Koskela, Lauri, Pikas, Ergo   +3 more
core  

Exact Spectral Analysis of Single-h and Multi-h CPM Signals through PAM decomposition and Matrix Series Evaluation

, 2006
In this paper we address the problem of closed-form spectral evaluation of CPM. We show that the multi-h CPM signal can be conveniently generated by a PTI SM.
Cariolaro, Gianfranco, Erseghe, Tomaso, Laurenti, Nicola, Pierobon, Gianfranco   +3 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Conditioned Pain Modulation Predicts Exercise-Induced Hypoalgesia in Healthy Adults [PDF]

, 2015
Introduction: Conditioned pain modulation (CPM) is the concept that pain inhibits pain and has potential rehabilitation implications for exercise prescription. The purpose of this study was to determine whether changes in pressure pain perception after a
Bement, Marie K. Hoeger, Hunter, Sandra K., Lemley, Kathy J.   +2 more
core   +1 more source